Chemical synthesis

Chemical synthesis is the process by which one or more chemical reactions are performed with the aim of converting a reactant or starting material into a product or multiple products. Chemical synthesis is at the heart of much chemistry research as it is the basis for discovering compounds with new physical or biological properties.


Latest Research and Reviews

News and Comment

  • News and Views |

    Methods for generating molecular diversity provide a route to screen a wider section of chemical space, to discover compounds with useful biological properties. Now, a complexity-to-diversity strategy has enabled the discovery of a multi-cyclic structure from a complex natural product that induces ferroptotic cell death in cancer cells.

    • Tatiana Cañeque
    •  & Raphaël Rodriguez
    Nature Chemistry 11, 499-500
  • Research Highlights |

    A rapid synthesis of the antibacterial drug linezolid using flow chemistry has been reported that does not require isolation or purification of any intermediates and is completed in seven synthetic steps

    • Stephen G. Davey
  • News and Views |

    The direct formation of C–N bonds onto arenes provides a simple route to synthesize a variety of important products. Now, formation of a highly polarized, aminium radical cation enables direct C–H amination, allowing the coupling of an exceptionally broad range of alkyl amines and arenes.

    • David Nagib
    Nature Chemistry 11, 396-398
  • News and Views |

    The diversity of engineered amine dehydrogenases for reductive amination remains limited. Now, native amino dehydrogenases offering a different sequence space and catalytic features are discovered — enhancing and broadening the biocatalysis toolbox.

    • Andreas S. Bommarius
    Nature Catalysis 2, 288-289
  • News and Views |

    Natural products often provide lead scaffolds for the development of therapeutics, but complexity of their synthesis can limit the discovery of improved analogues. Pharmacophore-directed retrosynthesis aims to accelerate the building of a structure–activity relationship profile of a natural product, aiming to identifying a simplified lead.

    • Jason R. Hudlicky
    •  & Gary A. Sulikowski
    Nature Chemistry 11, 297-298