Chemical synthesis

Chemical synthesis is the process by which one or more chemical reactions are performed with the aim of converting a reactant or starting material into a product or multiple products. Chemical synthesis is at the heart of much chemistry research as it is the basis for discovering compounds with new physical or biological properties.


Latest Research and Reviews

News and Comment

  • News & Views |

    Efforts to probe the biological functions of carbohydrates have long been limited by the lack of such molecules with well-defined structures. An automated carbohydrate synthesizer has been developed that could remedy this.

    • Hanchao Cheng
    •  & Peng George Wang
  • News & Views |

    A monocrystalline native oxide dielectric, β-Bi2SeO5, with a high dielectric constant has been synthesized by oxidizing a two-dimensional (2D) semiconductor, Bi2O2Se. In 2D transistors, the ultrathin β-Bi2SeO5 dielectric demonstrates sub-0.5-nm equivalent oxide thickness and leakage current below the low-power limit, meeting the requirements of the International Roadmap for Devices and Systems.

  • News & Views |

    The ozonolysis reaction is a classic of organic synthesis, but involves the formation of potentially explosive reaction intermediates. A modern, safer spin on this process makes use of previously overlooked chemistry.

    • Vignesh Palani
    •  & Alison Wendlandt
  • Research Highlights |

    Remarkably simple conditions can convert fac-Ir(iii) arylpyridine complexes to the less thermodynamically stable mer-isomers. The organoiridium complexes are considered highly effective luminescent molecular switches.

    • Stephanie Greed
  • News & Views |

    Amines with free N–H groups have long posed a tremendous challenge in transition metal-catalysed amination reactions. Now, use of a bidentate phosphorus ligand enables the palladium-catalysed oxidative amination of simple olefins with Lewis basic amines, with no prefunctionalization, forming both alkyl and aryl allylamines.

    • Logan E. Vine
    •  & Jennifer M. Schomaker
    Nature Chemistry 14, 1093-1094