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| Open AccessMembrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis
The authors describe the mechanism of exo-endocytosis coupling at synapses. They find that actin forms a ring around the region of exocytosis. This ring conserves membrane area, allowing induction of inward membrane buckling following exocytosis.
- Tyler H. Ogunmowo
- , Haoyuan Jing
- & Jian Liu
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Article
| Open AccessUltrastructural and functional fate of recycled vesicles in hippocampal synapses
Synaptic vesicles are efficiently retrieved after transmission but the contribution they make to future signalling remains unclear. Rey et al.find that only a subset of vesicles—typically those retrieved recently in the stimulus train—remain near the active zone and exhibit privileged use.
- Stephanie A. Rey
- , Catherine A. Smith
- & Kevin Staras
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Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons
During development, neurons prune their axons and dendrites to eliminate excessive or inappropriate connections initially formed but the mechanistic details of the pruning process are not completely understood. Here the authors visualize pruning events in dendritic branches in Drosophilaand study the role of calcium transients and endocytosis in this process.
- Takahiro Kanamori
- , Jiro Yoshino
- & Kazuo Emoto
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Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase
Dysregulation of the kinase Mnb is implicated in autism spectrum disorder and Down’s syndrome. Here the authors demonstrate that Mnb is required for correct synaptic morphology and synaptic vesicle endocytosis, which it achieves via phosphorylation of the synaptic endocytosis protein Synaptojanin.
- Chun-Kan Chen
- , Catherine Bregere
- & Karen T. Chang
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Article
| Open AccessControl of synaptic vesicle endocytosis by an extracellular signalling molecule
Synaptic vesicle endocytosis is required for neurotransmission at nerve terminals. Smillie et al. show that brain-derived neurotrophic factor inhibits a specific type of synaptic vesicle endocytosis, which reverses the depression of neurotransmission observed during high-intensity stimulation.
- Karen J. Smillie
- , Jonathan Pawson
- & Michael A. Cousin