Synaptic transmission

Synaptic transmission is the biological process by which a neuron communicates with a target cell across a synapse. Chemical synaptic transmission involves the release of a neurotransmitter from the pre-synaptic neuron, and neurotransmitter binding to specific post-synaptic receptors. Electrical synapse transmission involves the transfer of electrical signals through gap junctions.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Chandelier cells, a type of cortical interneuron targeting the axon initial segment of pyramidal cells are shown to monitor network activity and adjust their output in a homeostatic manner.

    • Sian Lewis
  • News and Views |

    Two new studies show that gliomas can manipulate normal elements of neuronal development and plasticity to create neuron–glia synapses, activation of which leads to glioma proliferation. Interventions that target the AMPA receptor could slow down tumour growth by altering this synaptic transmission.

    • Mary Jane Lim-Fat
    •  & Patrick Y. Wen
  • Research Highlights |

    Dendritic activation and action potentials lead to the expression of distinct heterodimers of the inducible transcription factor NPAS4, which show distinct DNA binding patterns; these patterns were recapitulated on exposure of mice to a novel environment.

    • Sian Lewis