Synaptic transmission articles from across Nature Portfolio

Synaptic transmission is the biological process by which a neuron communicates with a target cell across a synapse. Chemical synaptic transmission involves the release of a neurotransmitter from the pre-synaptic neuron, and neurotransmitter binding to specific post-synaptic receptors. Electrical synapse transmission involves the transfer of electrical signals through gap junctions.

Latest Research and Reviews

Reviews
01 June 2023 | Open Access

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
- Kyung Ah Han
- & Jaewon Ko
Experimental & Molecular Medicine, 1-11
Research
01 June 2023 | Open Access

Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA_A receptor transport in a murine model
- Jing Liu
- , Pingyang Ke
- & Fei Xiao
Experimental & Molecular Medicine, 1-15
Research
30 May 2023 | Open Access

Afferent convergence to a shared population of interneuron AMPA receptors

Glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of transmission called spillover. Here, the authors find in the cerebellar cortex that glutamate spillover from climbing fibers activates synaptic AMPA receptors of molecular layer interneurons, allowing glutamate from an unconnected pathway to co-opt postsynaptic receptors.
- Reagan L. Pennock
- , Luke T. Coddington
- & Jacques I. Wadiche
Nature Communications 14, 3113
Research
29 May 2023 | Open Access

Postsynaptic synucleins mediate endocannabinoid signaling

Endocannabinoids are important modulators of synaptic transmission, although their mechanism of release is unknown. In this study, the authors found that endocannabinoid postsynaptic release is mediated by synucleins via a synuclein-dependent and SNARE-dependent mechanism.
- Eddy Albarran
- , Yue Sun
- & Jun B. Ding
Nature Neuroscience, 1-11
Research
25 May 2023 | Open Access

Sex differences in VTA GABA transmission and plasticity during opioid withdrawal
- Daniel J. Kalamarides
- , Aditi Singh
- & John A. Dani
Scientific Reports 13, 8460
Research
24 May 2023 | Open Access

Homeostatic synaptic plasticity rescues neural coding reliability

How synaptic plasticity affects neural coding reliability is not well understood. Here, the authors find that reducing neurotransmitter release probability triggers a homeostatic compensation to maintain neural coding and behavioral reliability.
- Eyal Rozenfeld
- , Nadine Ehmann
- & Moshe Parnas
Nature Communications 14, 2993

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News and Comment

Research Highlights | 22 May 2023

A metabotropic receptor for glycine

The G-protein-coupled receptor GPR158 acts as a metabotropic glycine receptor in mice.
- Darran Yates
Nature Reviews Neuroscience, 1
Research Highlights | 05 May 2023

Neuron–glia communication through bona fide synapses
- Lucas Cheadle
Nature Reviews Neuroscience, 1
News & Views | 06 April 2023

Photon-based communication between two neurons in Caenorhabditis elegans

Cells exchange information with one another using secreted chemicals as data carriers. We developed an all-optogenetic synaptic transmission system that replaced a chemical neurotransmitter with emitted photons. This system enabled synthetic signaling between unconnected neurons and the generation of prosthetic synaptic circuits.

Nature Methods 20, 653-654
Research Highlights | 17 March 2023

SMN linked to SNARE complex assembly

New findings indicate a role for SMN protein in assembly of the synaptic SNARE complex at neuromuscular junctions, providing insight into mechanisms of pathology in spinal muscular atrophy.
- Katherine Whalley
Nature Reviews Neuroscience 24, 267
Research Highlights | 07 March 2023

Brain organoids fill the gap
- Beatriz Gomez Perez-Nievas
Nature Neuroscience 26, 365
Research Highlights | 17 February 2023

Classifying inhibitory synapses in the cortex: beyond cell types

Seung-Hee Lee describes findings published in 2000 that gave us insight into the principles by which different types of GABAergic synapses are organized in cortical networks.
- Seung-Hee Lee
Nature Reviews Neuroscience 24, 269

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Synaptic transmission articles from across Nature Portfolio

Latest Research and Reviews

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA_A receptor transport in a murine model

Afferent convergence to a shared population of interneuron AMPA receptors

Postsynaptic synucleins mediate endocannabinoid signaling

Sex differences in VTA GABA transmission and plasticity during opioid withdrawal

Homeostatic synaptic plasticity rescues neural coding reliability

News and Comment

A metabotropic receptor for glycine

Neuron–glia communication through bona fide synapses

Photon-based communication between two neurons in Caenorhabditis elegans

SMN linked to SNARE complex assembly

Brain organoids fill the gap

Classifying inhibitory synapses in the cortex: beyond cell types

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Synaptic transmission articles from across Nature Portfolio

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