Surface plasmon resonance

Surface plasmon resonance (SPR) spectroscopy is a technique to detect biomolecular binding interactions. In SPR, one molecular partner is immobilized on a metallic film. Light excites surface plasmons in the metal; when the binding partner binds to the immobilized molecule, this causes a detectable change in the surface plasmon signal.

Latest Research and Reviews

Research
10 November 2021 | Open Access

A Fabry-Pérot cavity coupled surface plasmon photodiode for electrical biomolecular sensing

Surface plasmon resonance is well established for biosensing applications, but commonly limited by complex optical detection. Here, the authors present a plasmonic sensor integrated in a photovoltaic cell, which generates an electronic signal sensitive to the solution refractive index via plasmon interaction
- Giles Allison
- , Amrita Kumar Sana
- & Hironori Suzuki
Nature Communications 12, 6483
Research
08 October 2021 | Open Access

High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes

The authors demonstrate a colourimetric imaging method using plasmonic nanoparticles for visualisation of heterochromatin histone markers. Based on the distance-dependent coupling effect, resulting in spectral shifts, they observe reorganisation of histone markers caused by oncogene-induced senescence.
- Hyun Ji An
- , Yun Kim
- & Inhee Choi
Nature Communications 12, 5899
Research
22 July 2021 | Open Access

Surface plasmon resonance unveils important pitfalls of enzyme-linked immunoassay for the detection of anti-infliximab antibodies in patients’ sera
- Marten Beeg
- , Cesare Burti
- & Marco Gobbi
Scientific Reports 11, 14976
Research
12 May 2021 | Open Access

A polyaniline/platinum coated fiber optic surface plasmon resonance sensor for picomolar detection of 4-nitrophenol
- Iulia Antohe
- , Iuliana Iordache
- & Gabriel Socol
Scientific Reports 11, 10086
Protocols | 30 April 2021

RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19

This protocol provides an RNA extraction–free nano-amplified colorimetric test that enables rapid detection of SARS-CoV-2 with the naked eye. The test uses plasmonic gold nanoparticles capped with antisense oligonucleotides as a colorimetric biosensor for point-of-care diagnosis of COVID-19.
- Maha Alafeef
- , Parikshit Moitra
- & Dipanjan Pan
Nature Protocols 16, 3141-3162
Reviews
15 January 2021 | Open Access

A comprehensive review on plasmonic-based biosensors used in viral diagnostics

Mohan, Abdulhalim and Cvelbar investigated the capabilities of different plasmonic-based sensing techniques including the surface plasmon resonance (SPR), localised SPR, surface-enhanced Raman scattering (SERS), surface-enhanced fluorescence (SEF) and surface-enhanced infrared absorption spectroscopy (SEIRA) for the detection of viruses. The presented data will assist in the development of novel and versatile virus biosensors.
- Anand M. Shrivastav
- , Uroš Cvelbar
- & Ibrahim Abdulhalim
Communications Biology 4, 70

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News and Comment

Research Highlights | 03 September 2021

Thermodynamic profiling of single molecules

A single-molecule calorimeter measures the thermodynamic properties of individual proteins.
- Rita Strack
Nature Methods 18, 989
Research Highlights | 30 July 2014

Etching away at the surface

Silver-based nanoparticles in combination with an etching procedure facilitate the analysis of cellular internalization processes.
- Nina Vogt
Nature Methods 11, 790
Research Highlights | 29 May 2014

Cellular imaging of single-splice variants

Nature Methods 11, 609
Research Highlights | 04 April 2011

DNA sensors: Playing the field

A promising plasmon-based DNA detection technique becomes more sensitive and accurate with the use of an electric field.

NPG Asia Materials, 1
News & Views | 31 October 2010

Plasmons offer a helping hand

Arrays of metallic nanostructures allow chiral biomolecules to be detected and characterized with increased sensitivity.
- Romain Quidant
- & Mark Kreuzer
Nature Nanotechnology 5, 762-763
News & Views | 29 September 2010

Dark-hot resonances

The resonant behaviour of clusters of gold nanoparticles has been tuned by gradually bringing the particles together. The approach could have many applications, including chemical and biological sensing.
- Mark I. Stockman
Nature 467, 541-542

All News & Comment

Surface plasmon resonance

Latest Research and Reviews

A Fabry-Pérot cavity coupled surface plasmon photodiode for electrical biomolecular sensing

High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes

Surface plasmon resonance unveils important pitfalls of enzyme-linked immunoassay for the detection of anti-infliximab antibodies in patients’ sera

A polyaniline/platinum coated fiber optic surface plasmon resonance sensor for picomolar detection of 4-nitrophenol

RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19

A comprehensive review on plasmonic-based biosensors used in viral diagnostics

News and Comment

Thermodynamic profiling of single molecules

Etching away at the surface

Cellular imaging of single-splice variants

DNA sensors: Playing the field

Plasmons offer a helping hand

Dark-hot resonances

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