Supramolecular chemistry

Supramolecular chemistry is the study of entities of greater complexity than individual molecules — assemblies of molecules that bond and organize through intermolecular interactions. The design and synthesis of supramolecular systems invokes interactions beyond the covalent bond, using, for example, hydrogen bonding, metal coordination and π interactions to bring discrete building blocks together.


Latest Research and Reviews

News and Comment

  • News and Views |

    After years of speculation on the origins of symmetry-making and -breaking during crystallization, time-resolved in situ scanning probe microscopy and all-atom molecular dynamics simulations have shown that the formation of olanzapine crystals largely occurs by the incorporation of centrosymmetric dimers into growth sites.

    • Susan M. Reutzel-Edens
  • Comments and Opinion |

    Manza B. J. Atkinson talks to Nature Chemistry about his path to become a chemist, and how he applies the scientific method to all aspects of his life — from financial analysis to coaching youth sports teams.

    • Anne Pichon
  • News and Views |

    Controlling the formation of ordered and predictable patterns in dissipative reaction–diffusion processes is challenging. Now, liquid vibrations induced by audible sound have been shown to direct the formation of spatiotemporal patterns in switchable chemical systems and assemblies.

    • Charalampos G. Pappas
    Nature Chemistry 12, 784-785
  • News and Views |

    Chemical systems can show complex behaviour that is not seen in individual molecules or reactions. Helena S. Azevedo, Sarah L. Perry, Peter A. Korevaar, and Dibyendu Das report on the emergence of this complex behaviour, which was discussed at the Virtual Symposium on Systems Chemistry

    • Helena S. Azevedo
    • , Sarah L. Perry
    • , Peter A. Korevaar
    •  & Dibyendu Das
    Nature Chemistry 12, 793-794
  • Research Highlights |

    Two templates can stack together to enable the formation of a large macrocycle, providing they bind cooperatively to the target. The approach may enable the synthesis of very large macrocycles using relatively simple templates.

    • Stephen G. Davey
  • Comments and Opinion |

    Despite the romantic mythology that often accompanies stories of scientific discovery, pinpointing the exact moment in history when a new concept emerged is often a matter of debate — and the hydrogen bond is no exception explains Bruce C. Gibb.

    • Bruce C. Gibb
    Nature Chemistry 12, 665-667