The striatum is a subcortical structure in the forebrain that forms the major input to the basal ganglia. The striatum can be further subdivided into dorsal (caudate, putamen) and ventral (nucleus accumbens), and is implicated in regulating motor behaviours and responses to rewarding and aversive stimuli.

Latest Research and Reviews

News and Comment

  • News & Views |

    In this issue of Nature Neuroscience, Menegas et al. demonstrate a role for midbrain dopamine neurons projecting to the tail of the striatum in encoding stimulus novelty and threat avoidance. From this study emerges a model whereby distinct dopaminergic projections to striatum influence behavior along at least two axes, one representing value and one representing threat.

    • Cody A. Siciliano
    • , Fergil Mills
    •  & Kay M. Tye
    Nature Neuroscience 21, 1296-1297
  • Research Highlights |

    Opiate drugs and opioid peptides differ in their effects on intracellular signalling, in which following ligand–receptor binding and internalization, opioids continue to signal from endosomes, whereas opiates activate receptors located at the Golgi.

    • Sian Lewis
  • Research Highlights |

    Disruption of actin polymerization in the frontal cortex, which causes abnormal dendritic spine structures, results in locomotor hyperactivity owing to dysregulation of a midbrain dopaminergic circuit.

    • Fiona Carr