Stress granules

Stress granules are aggregates composed of proteins and RNA molecules – mostly stalled translation initiation complexes – that usually form in a reversible manner upon cellular stress. Stress granules can also precipitate the formation of toxic protein aggregates such as those seen during the progression of certain types of neurological disease.

Latest Research and Reviews

News and Comment

  • News & Views |

    Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.

    • Christopher M. Jakobson
    •  & Daniel F. Jarosz
    Nature Cell Biology 23, 1053-1055
  • News & Views |

    Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.

    • Chih-Yung Lee
    •  & Geraldine Seydoux
    Nature Cell Biology 21, 116-117
  • News & Views |

    Phase separation can build assemblies and regulate biological function. Two articles link specific forms of protein and RNA degradation to phase separation. The polyubiquitin shuttle factor UBQLN2 localizes to stress granules where it may extract ubiquitinated proteins, and the miRISC complex functions through phase separation.

    • Tanja Mittag
    •  & Nicolas L. Fawzi
    Nature Cell Biology 20, 635-637