Stress granules articles within Nature Communications

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  • Article
    | Open Access

    The cell interior is organized by diverse membrane-less condensates. Here, the authors reveal that the densities of certain condensates are surprisingly low, similar to the surrounding protoplasm and driven by cellular RNA as well as the crowded milieu.

    • Taehyun Kim
    • , Jaeyoon Yoo
    •  & Yongdae Shin
  • Article
    | Open Access

    Stress granules are non-membranous organelles connected to stress responses and age-related disease. Here, the authors identify a conserved yeast protein, Lsm7, that facilitates stress granule formation through dynamic liquid-liquid phase separation condensates upon 2-deoxy-D-glucose-induced stress.

    • Michelle Lindström
    • , Lihua Chen
    •  & Beidong Liu
  • Article
    | Open Access

    Rbfox1, a pro-survival RNA-binding protein, is expressed in a complex manner and mediates diverse developmental processes. Here, the authors observe alternative splicing of Rbfox1 and stress-dependent regulation by miR-980 in Drosophila ovaries and Rbfox1 localisation in ribonucleoprotein granules in human cells.

    • Mariya M. Kucherenko
    •  & Halyna R. Shcherbata
  • Article
    | Open Access

    Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to arsenite exposure.

    • Aravinth Kumar Jayabalan
    • , Anthony Sanchez
    •  & Takbum Ohn