Stereochemistry is the scientific concept that describes the relationship between chemical compounds which have the same molecular formula and identical functional groups but with different three dimensional arrangements of atoms. These molecules are known as stereoisomers and can have very different properties from one another, particularly when interacting with biological systems.

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News and Comment

  • Comments and Opinion
    | Open Access

    After two decades of steady growing, symbiotic merger of organocatalysis with emerging electrochemical and photochemical tools are envisioned as hot topics in the coming decade. Here, these trends are discussed in parallel to the implementation of artificial intelligence-based technologies, which anticipate a paradigm shift in catalyst design.

    • José M. Lassaletta
  • Research Highlights |

    An unexpected epoxide deoxygenation reaction was observed to occur with inversion of stereochemistry and has enabled development of a method for alkene isomerization.

    • Stephen G. Davey
  • News and Views |

    The chemoenzymatic potential for the construction of complex chiral molecules has not been fully explored. Now, Candida antarctica lipase B has been used to synthesize complex functionalized planar chiral macrocycles, providing a platform for the efficient and sustainable preparation of molecules that are of particular interest in drug discovery.

    • Jose M. Palomo
    Nature Catalysis 3, 335-336
  • Comments and Opinion |

    Michelle Francl wonders if a molecule can be just a little bit chiral?

    • Michelle Francl
    Nature Chemistry 11, 597-598
  • News and Views |

    Strained boronate complexes have now been shown to enable an unprecedented cross-coupling reaction across a C–C σ-bond. Using this approach, highly functionalized cyclobutanes can be prepared with excellent stereocontrol from readily available reagents.

    • Alejandro Parra
    •  & Mariola Tortosa
    Nature Chemistry 11, 104-106
  • News and Views |

    Optimization of catalytic stereoselectivity for new substrates often requires a time consuming experimental process, and high-accuracy molecular modelling remains intractable for comprehensive virtual screening. Now, highly enantioselective rhodium hydrogenation catalysts have been identified using a rapid computational transition-state analysis protocol and then experimentally verified.

    • Daniel H. Ess