Featured
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Outlook |
The mouth’s curative superpowers
Wounds in the mouth heal faster than in skin — and without scarring. Could unravelling the mechanisms that drive regeneration in the oral cavity lead to better wound therapies?
- Natalie Healey
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Article
| Open Access
An atlas of cortical arealization identifies dynamic molecular signatures
RNA-sequencing analysis of the prenatal human brain at different stages of development shows that areal transcriptional signatures are dynamic and coexist with developmental and cell-type signatures.
- Aparna Bhaduri
- , Carmen Sandoval-Espinosa
- & Arnold R. Kriegstein
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Outlook |
Stem cells
The vast potential of these building blocks of regenerative medicine is coming closer to being realized.
- Richard Hodson
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Outlook |
Stem cells and spinal-cord injuries: an intricate issue
Neuroscientist Aileen Anderson explains why cell therapy to bridge severed neurons has proved more difficult than expected.
- Lauren Gravitz
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Outlook |
Stem cells: highlights from research
Self-organizing models of the early heart, why dead cells can be therapeutic, and other studies.
- Anthony King
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Outlook |
Reversing blindness with stem cells
Regenerative therapies for the eyes could help to save vision in people with glaucoma, macular degeneration and damaged corneas.
- Neil Savage
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Outlook |
The promise and potential of stem cells in Parkinson’s disease
Treatments that replace lost neurons and restore normal movement have entered clinical trials, but these therapies could offer more relief than cure.
- Lauren Gravitz
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Outlook |
The rise of the assembloid
3D models of biological tissue that incorporate multiple cell types are the latest tools for understanding human development and disease.
- Charlie Schmidt
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Outlook |
Why stem cells might save the northern white rhino
Biologist Jeanne Loring explains how her work could bring endangered animal species back from the brink.
- Julianna Photopoulos
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Outlook |
The chimaera challenge
The ability to develop animals that have human organs could save the lives of people waiting for transplants, but ethical issues still need to be faced.
- Liam Drew
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Outlook |
Stem-cell start-ups seek to crack the mass-production problem
Commercial outfits are building the tools and know-how to manufacture treatments using induced pluripotent stem cells in the quantities required for clinical use.
- Eric Bender
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Outlook |
The next frontier for human embryo research
Keeping human embryos alive in a dish is getting easier. How are researchers and ethicists responding?
- Elizabeth Svoboda
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Article |
Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis
A rare population of acinar cells expressing telomerase reverse transcriptase renew the acinar cell compartment during homeostasis, and are potential sources of premalignant cells in pancreatic carcinogenesis.
- Patrick Neuhöfer
- , Caitlin M. Roake
- & Steven E. Artandi
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Article |
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche
Computational modelling and mouse genetics approaches show that multipotent progenitor cells that have the potential to populate the hepato-pancreato-biliary lineage tree persist in the pancreato-biliary organ rudiment.
- David Willnow
- , Uwe Benary
- & Francesca M. Spagnoli
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Article |
Aged skeletal stem cells generate an inflammatory degenerative niche
An analysis of skeletal stem cells in mice reveals that bone ageing occurs at the level of local niches affecting skeletal and haematopoietic lineage output, which may influence systemic aspects of multi-organ physiological ageing.
- Thomas H. Ambrosi
- , Owen Marecic
- & Charles K. F. Chan
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News & Views |
A stem-cell basis for skeletal ageing
How ageing contributes to bone loss is unclear. In ageing mice, skeletal stem cells lose their ability to generate bone-forming cells called osteoblasts, and instead promote the generation of bone-resorbing cells called osteoclasts.
- Matthew B. Greenblatt
- & Shawon Debnath
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Correspondence |
ISSCR guidelines uphold human right to science for benefit of all
- Zubin Master
- , Robin Lovell-Badge
- & Bartha Knoppers
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Outlook |
How stem cells could fix type 1 diabetes
Trials to replace the pancreatic β cells that are destroyed by this autoimmune disease are raising hopes of a cure.
- Liam Drew
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Outlook |
Miniature organs to heal damaged livers
The start-up Bilitech hopes organoids could be used as an alternative to liver transplants, to save lives and money.
- Benjamin Plackett
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Article |
Obesity accelerates hair thinning by stem cell-centric converging mechanisms
Obesity in mice, caused by a high-fat diet, induces hair loss as a result of changes in the differentiation of hair follicle stem cells.
- Hironobu Morinaga
- , Yasuaki Mohri
- & Emi K. Nishimura
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Correspondence |
ISSCR: grave omission of age limit for embryo research
- Josephine Johnston
- , Françoise Baylis
- & Henry T. Greely
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Correspondence |
Don’t abandon 14-day limit on embryo research, it makes sense
- Ronald M. Green
- , Michael D. West
- & Leonard Hayflick
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Outlook |
Heart health
Research is revealing the causes of heart disease and what can be done to tackle the world’s biggest killer.
- Herb Brody
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Outlook |
Cells or drugs? The race to regenerate the heart
Researchers are debating how to convince the heart to heal itself instead of laying down scar tissue after a heart attack.
- Benjamin Plackett
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News & Views |
A 4D road map for the formation of hair follicles
Combined imaging and gene-expression analyses reveal that the arrangement of cells in concentric rings in the disc-like structures that give rise to hair follicles predetermines their eventual fate and location in mature follicles.
- Nivedita Saxena
- & Michael Rendl
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Article |
Tracing the origin of hair follicle stem cells
Live imaging and single-cell transcriptomics of mouse hair follicles reveal their development from 2D concentric zones in the placode to 3D longitudinal compartments, one of which is a stem cell compartment.
- Ritsuko Morita
- , Noriko Sanzen
- & Hironobu Fujiwara
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News & Views |
Cancer stem cells in the gut have a bad influence on neighbouring cells
Malignant stem cells in the gut secrete factors that promote the differentiation of neighbouring stem cells, thereby aiding the replacement of normal stem cells by those with cancer-promoting mutations.
- Shi Biao Chia
- & James DeGregori
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Article |
Tracing oncogene-driven remodelling of the intestinal stem cell niche
By inducing changes in surrounding tissue, mutant intestinal stem cells create an unfavourable niche environment that gives them a competitive advantage over non-mutant neighbours.
- Min Kyu Yum
- , Seungmin Han
- & Benjamin D. Simons
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Article |
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
NOTUM from Apc-mutant cells acts as a key mediator during the early stages of mutation fixation and drives the formation of intestinal adenomas.
- Dustin J. Flanagan
- , Nalle Pentinmikko
- & Owen J. Sansom
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Article |
Apc-mutant cells act as supercompetitors in intestinal tumour initiation
Using experiments in organoids and in vivo in mice, the authors show that Apc-mutant cells act as supercompetitors to initiate the formation of adenomas.
- Sanne M. van Neerven
- , Nina E. de Groot
- & Louis Vermeulen
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World View |
Stem-cell guidelines: why it was time for an update
New oversight criteria aim to reassure the public and permit progress in contentious research, such as growing human embryos in the lab.
- Robin Lovell-Badge
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News |
Limit on lab-grown human embryos dropped by stem-cell body
The International Society for Stem Cell Research relaxed the famous 14-day rule on culturing human embryos in its latest research guidelines.
- Nidhi Subbaraman
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Nature Podcast |
New hope for vaccine against a devastating livestock disease
A vaccine candidate for a neglected tropical disease, and calls to extend the 14-day limit on embryo research.
- Benjamin Thompson
- & Shamini Bundell
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Article |
Global miRNA dosage control of embryonic germ layer specification
The levels of microRNAs in mouse and human cells control lipid metabolism and germ cell specification during development.
- Yingzi Cui
- , Xuehui Lyu
- & Richard I. Gregory
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News Feature |
These cellular clocks help explain why elephants are bigger than mice
Biologists are uncovering how tiny timekeepers in our cells might govern body size, lifespan and ageing.
- Michael Marshall
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Technology Feature |
Elusive cancer cells dissected using developmental-biology toolkit
Unpicking how cancer stem cells divide and spread could help to explain how tumours grow and evade treatments.
- Jyoti Madhusoodanan
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News |
NIH reverses Trump-era restrictions on fetal-tissue research
The US National Institutes of Health will remove limits on government scientists and cancel a controversial grant-reviewing ethics panel.
- Nidhi Subbaraman
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News |
First monkey–human embryos reignite debate over hybrid animals
The chimaeras lived up to 19 days — but some scientists question the need for such research.
- Nidhi Subbaraman
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Article |
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Stress inhibits hair growth in mice through the release of the stress hormone corticosterone from the adrenal glands, which inhibits the activation of hair follicle stem cells by suppressing the expression of a secreted factor, GAS6, from the dermal niche.
- Sekyu Choi
- , Bing Zhang
- & Ya-Chieh Hsu
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News & Views |
Relax to grow more hair
A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice. When this signalling is blocked, hair growth is stimulated. Stressed humans, watch out.
- Rui Yi
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Article |
Blastocyst-like structures generated from human pluripotent stem cells
An in vitro culture strategy enables the generation of blastocyst-like structures termed human blastoids from naive human pluripotent stem cells, providing a model for studying human embryogenesis.
- Leqian Yu
- , Yulei Wei
- & Jun Wu
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News & Views |
First complete model of the human embryo
Early in development, human embryos form a structure called the blastocyst. Two research groups have now generated human blastocyst-like structures from cells in a dish, providing a valuable model for advancing human embryology.
- Yi Zheng
- & Jianping Fu
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News |
Lab-grown structures mimic human embryo's earliest stage yet
The experiments use human cells to imitate the blastocyst phase — offering a crucial window into human development.
- Nidhi Subbaraman
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Article |
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment
Cortical organoids derived from tetraploid human–chimpanzee fused induced pluripotent stem cells provide a platform for untangling unique molecular features of human brain development.
- Rachel M. Agoglia
- , Danqiong Sun
- & Hunter B. Fraser
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News |
Scientists grew tiny tear glands in a dish — then made them cry
Organoids made of tear-producing cells offer chances to study, and possibly treat, eye disorders.
- Heidi Ledford
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Article |
The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity
N6-methyladenosine RNA and its reader YTHDC1 serve as a bridge to silencing retrotransposons through the RNA derived from these retrotransposons in mouse ES cells.
- Jiadong Liu
- , Mingwei Gao
- & Jiekai Chen
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News & Views |
Exercise generates immune cells in bone
A specialized type of bone-cell progenitor has been identified in the bone marrow, and shown to support the generation of immune cells called lymphocytes in response to movement.
- Mehmet Saçma
- & Hartmut Geiger
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Article |
A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
A peri-arteriolar niche in the bone marrow for osteogenesis and lymphopoiesis is maintained by mechanical stimulation and is depleted during ageing.
- Bo Shen
- , Alpaslan Tasdogan
- & Sean J. Morrison
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Article |
An organoid-based organ-repurposing approach to treat short bowel syndrome
In a rat model of short bowel syndrome, transplantation of small intestinal organoids into the colon partially restores intestinal function and improves survival—a proof of principle that organoid transplantation might have therapeutic benefit.
- Shinya Sugimoto
- , Eiji Kobayashi
- & Toshiro Sato
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