Stem-cell niche

A stem-cell niche is an area of a tissue that provides a specific microenvironment, in which stem cells are present in an undifferentiated and self-renewable state. Cells of the stem-cell niche interact with the stem cells to maintain them or promote their differentiation.

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News & Views | 30 January 2023

Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression

Nature Cell Biology, 1-2

Latest Research and Reviews

Research
30 January 2023 | Open Access

Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function

Mesenchymal-epithelial crosstalk plays a key role in gut development and stem cell homeostasis, though underlying mechanisms are still unclear. Here, the authors demonstrate that mesenchymal Polycomb Repressive Complex 2 controls niche signals for gut epithelial fate and growth.
- Ryan J. Smith
- , Minggao Liang
- & Tae-Hee Kim
Nature Communications 14, 497
Research | 30 January 2023

Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression

Martino, Sunkara et al. report that endothelin produced by hair follicle progenitors binds to endothelin receptors on dermal sheath cells to trigger their contraction and hair follicle regression.
- Pieter Martino
- , Raghava Sunkara
- & Michael Rendl
Nature Cell Biology, 1-13
Research
14 January 2023 | Open Access

Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors
- Matteo Togninalli
- , Andrew T. V. Ho
- & Helen M. Blau
npj Regenerative Medicine 8, 4
Research
29 November 2022 | Open Access

Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects
- Yuuki Shirai
- , Junko Okano
- & Hideto Kojima
Scientific Reports 12, 20589
Research
24 November 2022 | Open Access

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

Here Kim et al. show that primary BMECs can be maintained ex vivo as distinct sinusoidal- and arterial-like populations and that the presence of macrophages is critical to preserve their native transcriptomic profiles and functional heterogeneity.
- Young-Woong Kim
- , Greta Zara
- & Nadia Carlesso
Nature Communications 13, 7235
Research
19 November 2022 | Open Access

Keratin-mediated hair growth and its underlying biological mechanism

Injecting human hair-derived keratin into mice skin accelerates hair growth & formation, as TGFβ2 secretion during hair destruction stimulates epithelial cell death and keratin release, leading to dermal cell condensation & hair growth.
- Seong Yeong An
- , Hyo-Sung Kim
- & Yu-Shik Hwang
Communications Biology 5, 1270

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News and Comment

News & Views | 30 January 2023

Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression

Contraction of the hair follicle-lining dermal sheath smooth muscle generates the forces necessary for the tissue remodelling that takes place during the regression phase of the hair growth cycle. This study reveals that endothelin signalling — from epithelial progenitors at the follicle bottleneck region to its neighbouring dermal sheath — is the main contraction-activating pathway.

Nature Cell Biology, 1-2
Research Highlights | 02 December 2022

p16^INK4a in lung repair
- Tim Thomas
Nature Aging 2, 1084
News | 06 September 2022

Hi, new PI

Your name is on the door to your new lab. Life is getting exciting and turbulent.
- Vivien Marx
Nature Methods 19, 1014
News & Views | 15 July 2022

Niche stiffness regulates stem cell aging

The microenvironment can regulate adult stem cell function during tissue homeostasis and regeneration, but whether and how this is altered in aging is unclear. Ichijo et al. find that increased dermal stiffness, as a result of vasculature atrophy, activates cation channel PIEZO1, leading to interfollicular epidermal stem cell dysregulation.
- Chae Ho Lim
- & Mayumi Ito
Nature Aging 2, 568-569
News & Views | 18 May 2022

Apelin drives endothelial cell migration toward intestinal progenitor cells

Elucidation of the mechanisms that drive tumor resistance to anti-angiogenic therapies is expected to improve treatment options. This report shows that endothelial apelin signaling promotes the migration of distant venous endothelial cells toward the tumor progenitor cell niche to support vessel expansion and sustain a normoxic microenvironment, and that it does so independently of vascular endothelial growth factor A.

Nature Cardiovascular Research 1, 546-547
Research Highlights | 19 January 2022

Cardiovascular disease alters the bone marrow vasculature

A new study shows that cardiovascular diseases remodel the bone marrow vasculature, inducing endothelial dysfunction, vascular leakage, fibrosis and angiogenesis and ultimately leading to overproduction of the inflammatory leukocytes implicated in these conditions.
- Irene Fernández-Ruiz
Nature Reviews Cardiology 19, 147

All News & Comment

Stem-cell niche

Featured

Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression

Latest Research and Reviews

Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function

Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression

Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors

Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

Keratin-mediated hair growth and its underlying biological mechanism

News and Comment

Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression

p16^INK4a in lung repair

Hi, new PI

Niche stiffness regulates stem cell aging

Apelin drives endothelial cell migration toward intestinal progenitor cells

Cardiovascular disease alters the bone marrow vasculature

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