Stem-cell differentiation articles from across Nature Portfolio

Adoptive immunotherapy, particularly chimeric antigen receptor (CAR)-T cells, has had considerable success in treating haematological malignancies. However, the variability, time commitment and cost of engineering cells limit their application. Human pluripotent stem (hPS) cells could provide an off-the-shelf, cheaper and scalable solution.

Over the past fifty years, intellectual property has not played a major role in the spread of assisted reproductive technology, but with in vitro gametogenesis — a technique likely to dominate the future of reproduction — it might.

Osteoarthritis is highly heterogeneous, so effective therapies will need to target clearly defined molecular endotypes, restore mechanical joint function and reduce pain; thus, a ‘one-size-fits-all’ approach is unlikely to succeed.

OCTOPUS is a bioengineered device for high-fidelity organoid cultures long term.

The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.