Stalled forks

Replication fork stalling occurs if the replication proteins, or replisome, encounter problems. Stalled forks activate checkpoint signalling and therefore pause replication.

Latest Research and Reviews

News and Comment

  • News and Views |

    Determining the molecular mechanisms responsible for trinucleotide DNA repeat expansions is critical, as such expansions underlie many neuromuscular and neurodegenerative disorders. Mirkin and colleagues now propose that large-scale expansions of trinucleotide repeats can be generated by DNA-break-induced replication.

    • Juraj Kramara
    • , Beth Osia
    •  & Anna Malkova
  • News and Views |

    Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress.

    • Vasily S. Romanov
    •  & K. Lenhard Rudolph
    Nature Cell Biology 18, 722-724