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Spine regulation is the biological process by which the structure or function of a dendritic spine is modulated by factors such as neuronal excitation. The structure of dendritic spines is highly variable; however, a typical spine consists of a spine head that may be mushroom- or cup-shaped and a thinner neck region.
The binding of psychedelics to the BDNF receptor TrkB boosts plasticity in cultured neurons and underlies the antidepressant-like effects of these compounds in mice.
