Spike-timing-dependent plasticity

Spike-timing-dependent plasticity (STDP) is a process by which synaptic transmission is enhanced or depressed. In STDP, the precise relative timing of presynaptic and postsynaptic action potentials determines the strength of synaptic potentiation or depression.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Dopamine regulates reinforcement-based plasticity at the single-spine level on medium spiny neurons in the striatum by increasing the gain of Hebbian plasticity.

    • Leonie Welberg
  • News & Views |

    A study shows that NR3A–containing presynaptic NMDA receptors regulate glutamate release, and that a switch in subunit composition underlies the developmental loss of spike timing–dependent LTD at cortical synapses.

    • Andrés Buonanno
    Nature Neuroscience 14, 274-276