Solid-state NMR articles from across Nature Portfolio

Nominally anhydrous minerals composing Earth’s and planetary rocks incorporate microscopic amounts of volatiles whose distribution affects their physical properties. Here the authors present an approach for trace-element quantification using micro-scale Nuclear Magnetic Resonance spectroscopy.

Here, the authors use cryo-electron microscopy and solid-state NMR in concert to determine a distinctive W-shaped parallel β-sheet structure of in-vitro-prepared E22G Aβ40 fibrils.

Receptor-interacting protein kinase 1 (RIPK1) plays key roles in regulating multiple signalling pathways. Here, using solid state NMR, the authors report the amyloid structure of mouse RIPK1, formed by an 82-residue sequence centred at RHIM: it adopts an “N”-shaped folding of the protein subunit in the fibril.

Unveiling the regulatory mechanism of regioselectivity in hydroformylation has been a significant challenge. Here the authors successfully demonstrate how hemilabile coordination influences regioselectivity by employing various in situ techniques.

Echinocandins inhibit the biosynthesis of β−1,3-glucan, an essential component of the fungal cell wall, but their efficacy against the pathogen Aspergillus fumigatus is limited. Here, Dickwella Widanage et al. show that A. fumigatus responds to echinocandin treatment by remodelling various cell wall polymers, thus maintaining cell wall integrity and modulating the permeability and circulation of the drug in the cell wall.

We demonstrated increased phospholipid peroxidation due to the formation of monolysocardiolipin–cytochrome c complexes in tafazzin-deficient models of Barth syndrome. We found that a specific anti-peroxidase agent inhibited this complex and improved mitochondrial respiration. Thus, targeting the deleterious peroxidase activity offers a potential therapeutic approach to treat Barth syndrome.

Elucidating the reaction mechanism of a catalytic process is very challenging. Now, advanced solid-state nuclear magnetic resonance experiments demonstrate the importance of oxygenates to regulate the conversion of synthesis gas over an oxide–zeolite-based bifunctional catalyst material.

An article in the Proceedings of the National Academy of Sciences reports a surface treatment method that enables biocompatible, versatile and chemically stable functionalization of diamond quantum sensors.

A newly developed method allows structure elucidation of proteins inside intact mammalian cells, using solid-state NMR spectroscopy.

Sporopollenin, which encapsulates gametes in spore and pollen grains, is probably the most chemically inert biopolymer. This inertness is essential for gamete protection, but also hinders the elucidation of sporopollenin molecular structure. Now, the macromolecular network forming sporopollenin is described in unprecedented detail.

Generating pure spin currents is a necessary part of many spintronic devices. Now there is a new mechanism for doing this, utilizing nuclear spin waves.