Single-molecule biophysics

Single-molecule biophysics is the study of the dynamics and interactions of individual biomolecules to understand how they carry out their functions in living cells. For example, monitoring the folding properties of single protein or RNA molecules helps reveal how they are transported across cellular membranes.

Latest Research and Reviews

News and Comment

  • News & Views |

    RNA knot-like structures function as an efficient physical barrier to RNA exoribonucleases. Single-molecule mechanical manipulation is used to unfold these structures and unravel the cause of their unusual mechanical resistance from a different direction.

    • Pan T. X. Li
  • News & Views |

    Single-molecule experiments can now quantify the surface forces that compete to package tethered DNA into a protein-rich condensate — providing much-needed mechanistic insight into the phase behaviour of the entangled genome in the nucleus.

    • Marina Feric
    Nature Physics 17, 981-982
  • News |

    Reaching ground truth in super-res microscopy, powered by a love of cooking and food.

    • Vivien Marx
    Nature Methods 18, 579
  • Research Highlights |

    Photonic resonator interferometric scattering microscopy offers label-free imaging of biomolecules in vitro with improved signal-to-noise ratio.

    • Rita Strack
    Nature Methods 18, 447