Signal transduction

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Latest Research and Reviews

  • Research |

    • Ganesh R. Pathare
    • , Alexiane Decout
    • , Selene Glück
    • , Simone Cavadini
    • , Kristina Makasheva
    • , Ruud Hovius
    • , Georg Kempf
    • , Joscha Weiss
    • , Zuzanna Kozicka
    • , Baptiste Guey
    • , Pauline Melenec
    • , Beat Fierz
    • , Nicolas H. Thomä
    •  & Andrea Ablasser
    Nature, 1-8
  • Research |

    Autophagy controls cellular homeostasis and influences immune responses. Galluzzi and colleagues show that tumor cell autophagy opposes inflammatory cell death following radiation therapy and can be inhibited to enhance antitumor responses.

    • Takahiro Yamazaki
    • , Alexander Kirchmair
    • , Ai Sato
    • , Aitziber Buqué
    • , Marissa Rybstein
    • , Giulia Petroni
    • , Norma Bloy
    • , Francesca Finotello
    • , Lena Stafford
    • , Esther Navarro Manzano
    • , Francisco Ayala de la Peña
    • , Elena García-Martínez
    • , Silvia C. Formenti
    • , Zlatko Trajanoski
    •  & Lorenzo Galluzzi
    Nature Immunology 21, 1160-1171
  • Research
    | Open Access

    Glucocorticoids (GC) are commonly used to suppress undesirable inflammatory responses. Here the authors show, using hi-dimensional flow cytometry data, that GC treatment following major surgeries alters adaptive immunity without significant modulation of innate immune responses or pain/functional impairment.

    • Edward A. Ganio
    • , Natalie Stanley
    • , Viktoria Lindberg-Larsen
    • , Jakob Einhaus
    • , Amy S. Tsai
    • , Franck Verdonk
    • , Anthony Culos
    • , Sajjad Ghaemi
    • , Kristen K. Rumer
    • , Ina A. Stelzer
    • , Dyani Gaudilliere
    • , Eileen Tsai
    • , Ramin Fallahzadeh
    • , Benjamin Choisy
    • , Henrik Kehlet
    • , Nima Aghaeepour
    • , Martin S. Angst
    •  & Brice Gaudilliere
  • Research |

    How Lck is recruited to the TCR to initiate signaling is not well known. Here Minguet and colleagues report a previously unknown binding motif in the CD3ε cytoplasmic tail that interacts in a noncanonical mode with the Lck SH3 domain that may help to improve TCR activation and the antitumor activity of a clinically approved CAR.

    • Frederike A. Hartl
    • , Esmeralda Beck-Garcìa
    • , Nadine M. Woessner
    • , Lea J. Flachsmann
    • , Rubí M.-H. Velasco Cárdenas
    • , Simon M. Brandl
    • , Sanaz Taromi
    • , Gina J. Fiala
    • , Anna Morath
    • , Pankaj Mishra
    • , O. Sascha Yousefi
    • , Julia Zimmermann
    • , Nico Hoefflin
    • , Maja Köhn
    • , Birgitta M. Wöhrl
    • , Robert Zeiser
    • , Kristian Schweimer
    • , Stefan Günther
    • , Wolfgang W. Schamel
    •  & Susana Minguet
    Nature Immunology 21, 902-913

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