Signal processing

  • Article
    | Open Access

    Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutation

    • Susan A. Kennedy
    • , Mohamed-Ali Jarboui
    •  & Walter Kolch
  • Article
    | Open Access

    Crosstalk between genetic circuits is a major challenge for engineering sophisticated networks. Here the authors design networks that compensate for crosstalk by integrating, not insulating, pathways.

    • Isaak E. Müller
    • , Jacob R. Rubens
    •  & Timothy K. Lu
  • Article
    | Open Access

    Chemical perturbation of specific protein–protein interactions is notoriously difficult, yet necessary when complete inhibition of a signalling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first-in-class small molecules that specifically inhibit TNF-induced NF-κB activation.

    • Nicolas A. Pabon
    • , Qiuhong Zhang
    •  & Robin E. C. Lee
  • Article
    | Open Access

    Individual animals have vocal signatures, but are the same signatures consistent across behavioral contexts? Here, the authors use behavioral experiments and acoustic analyses to show that zebra finches have distinct vocal signatures for different call types, such as aggression and long-distance contact.

    • Julie E. Elie
    •  & Frédéric E. Theunissen
  • Article
    | Open Access

    Cells constantly integrate information from multiple stimuli. By considering every possible means by which two stimuli can interact, Cappuccio et al. define 10 interaction modes and demonstrate their preferential use by dendritic cells responding to different combinations of microbial and host inflammatory cues.

    • Antonio Cappuccio
    • , Raphaël Zollinger
    •  & Vassili Soumelis