Signal processing articles within Nature Communications

Featured

• Article
  30 October 2023 | Open Access

  Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation

  The transcriptional regulator YAP controls cellular decisions such as proliferation, differentiation, and pluripotency. Here, the authors show a concentration-dependent and temporal communication code for YAP that enables cells to choose between these programs.

  • Kirstin Meyer
  • , Nicholas C. Lammers
  •  & Orion D. Weiner

• Article
  12 May 2022 | Open Access

  Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine

  Light-oxygen-voltage (LOV) photoreceptors perceive blue light to elicit spatio-temporally defined cellular responses, and their signalling process has been extensively characterized. Here the authors report that the light signal is still transduced in the absence of a conserved Gln residue, thought to be key.

  • Julia Dietler
  • , Renate Gelfert
  •  & Andreas Möglich

• Article
  31 March 2022 | Open Access

  Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles

  Phosphorylation networks are frequently at the heart of complex cellular decision making. Here the authors engineer synthetic phosphorylation devices with feedback regulation in mammalian cells and demonstrate how to use these to achieve tunable and robust control of cell behaviours.

  • Ross D. Jones
  • , Yili Qian
  •  & Ron Weiss

• Article
  16 November 2021 | Open Access

  Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing

  Here the authors use optogenetic tools to directly measure spatial signal processing in leukocyte chemotaxis. Their results reveal the importance of multiple negative feedback loops for maintaining spatial information in chemotaxis.

  • George R. R. Bell
  • , Esther Rincón
  •  & Sean R. Collins

• Article
  24 January 2020 | Open Access

  Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

  Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutation

  • Susan A. Kennedy
  • , Mohamed-Ali Jarboui
  •  & Walter Kolch

• Article
  06 September 2019 | Open Access

  Gene networks that compensate for crosstalk with crosstalk

  Crosstalk between genetic circuits is a major challenge for engineering sophisticated networks. Here the authors design networks that compensate for crosstalk by integrating, not insulating, pathways.

  • Isaak E. Müller
  • , Jacob R. Rubens
  •  & Timothy K. Lu

• Article
  26 February 2019 | Open Access

  A network-centric approach to drugging TNF-induced NF-κB signaling

  Chemical perturbation of specific protein–protein interactions is notoriously difficult, yet necessary when complete inhibition of a signalling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first-in-class small molecules that specifically inhibit TNF-induced NF-κB activation.

  • Nicolas A. Pabon
  • , Qiuhong Zhang
  •  & Robin E. C. Lee

• Article
  02 November 2018 | Open Access

  An information-theoretic framework for deciphering pleiotropic and noisy biochemical signaling

  Signalling responses are marked by substantial cell-to-cell variability. Here, the authors propose an information theoretic framework that accounts for multiple inputs and temporal dynamics to analyse how signals flow through shared network components.

  • Tomasz Jetka
  • , Karol Nienałtowski
  •  & Michał Komorowski

• Article
  02 October 2018 | Open Access

  Zebra finches identify individuals using vocal signatures unique to each call type

  Individual animals have vocal signatures, but are the same signatures consistent across behavioral contexts? Here, the authors use behavioral experiments and acoustic analyses to show that zebra finches have distinct vocal signatures for different call types, such as aggression and long-distance contact.

  • Julie E. Elie
  •  & Frédéric E. Theunissen

• Article
  21 April 2015 | Open Access

  Combinatorial code governing cellular responses to complex stimuli

  Cells constantly integrate information from multiple stimuli. By considering every possible means by which two stimuli can interact, Cappuccio et al. define 10 interaction modes and demonstrate their preferential use by dendritic cells responding to different combinations of microbial and host inflammatory cues.

  • Antonio Cappuccio
  • , Raphaël Zollinger
  •  & Vassili Soumelis