Sequencing

Sequencing refers to the techniques used to determine the primary structure of an unbranched biopolymer (DNA, RNA, protein, carbohydrate) resulting in a symbolic linear depiction of the monomeric subunits which summarizes much of the atomic-level structure of the molecule.

Latest Research and Reviews

News and Comment

  • Comments and Opinion |

    The UCSC SARS-CoV-2 Genome Browser ( https://genome.ucsc.edu/covid19.html ) is an adaptation of our popular genome-browser visualization tool for this virus, containing many annotation tracks and new features, including conservation with similar viruses, immune epitopes, RT–PCR and sequencing primers and CRISPR guides. We invite all investigators to contribute to this resource to accelerate research and development activities globally.

    • Jason D. Fernandes
    • , Angie S. Hinrichs
    • , Hiram Clawson
    • , Jairo Navarro Gonzalez
    • , Brian T. Lee
    • , Luis R. Nassar
    • , Brian J. Raney
    • , Kate R. Rosenbloom
    • , Santrupti Nerli
    • , Arjun A. Rao
    • , Daniel Schmelter
    • , Alastair Fyfe
    • , Nathan Maulding
    • , Ann S. Zweig
    • , Todd M. Lowe
    • , Manuel Ares Jr
    • , Russ Corbet-Detig
    • , W. James Kent
    • , David Haussler
    •  & Maximilian Haeussler
    Nature Genetics 52, 991-998
  • Research Highlights |

    BRICseq provides access to brain-wide connectivity and can be combined with functional and transcriptomic studies for a comprehensive view of neuronal circuitry.

    • Nina Vogt
    Nature Methods 17, 873
  • Research Highlights |

    A recent study combines CRISPR-based perturbation with single-cell RNA sequencing to characterize the roles of epigenome regulator proteins in controlling cell fate and identity during embryonic development.

    • Darren J. Burgess
  • Comments and Opinion |

    Thirty years on from the launch of the Human Genome Project, Richard Gibbs reflects on the promisesthat this voyage of discovery bore. Its success should be measured by how this project transformed the rules of research, the way of practising biological discovery and the ubiquitous digitization of biological science.

    • Richard A. Gibbs