Sepsis

Sepsis is a life-threatening condition that is caused by an excessive immune response to an infection, most commonly a bacterial infection. Sepsis can lead to multi-organ failure and death.

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  • Research
    | Open Access

    Ultrasensitive methods for detection of biomarkers for infectious disease are needed for diagnosing, monitoring and targeting treatment. Here the authors develop a digital assay for inflammatory markers, bacterial DNA and antibotic-resistance genes and apply it to characterise asthma patients and predict mortality from septic shock.

    • M. Fatih Abasıyanık
    • , Krysta Wolfe
    • , Hoang Van Phan
    • , Jing Lin
    • , Bharathi Laxman
    • , Steven R. White
    • , Philip A. Verhoef
    • , Gökhan M. Mutlu
    • , Bhakti Patel
    •  & Savaş Tay
  • Research
    | Open Access

    Sepsis due to multidrug resistant pathogens is the most common cause of death in intensive care units. Here, the authors report that fecal microbiota transplant (FMT) can rescue mice from lethal sepsis of pathogens isolated from stool of a critically ill patient and show that FMT reverses the immunosuppressive effect induced by the pathogen community.

    • Sangman M. Kim
    • , Jennifer R. DeFazio
    • , Sanjiv K. Hyoju
    • , Kishan Sangani
    • , Robert Keskey
    • , Monika A. Krezalek
    • , Nikolai N. Khodarev
    • , Naseer Sangwan
    • , Scott Christley
    • , Katharine G. Harris
    • , Ankit Malik
    • , Alexander Zaborin
    • , Romain Bouziat
    • , Diana R. Ranoa
    • , Mara Wiegerinck
    • , Jordan D. Ernest
    • , Baddr A. Shakhsheer
    • , Irma D. Fleming
    • , Ralph R. Weichselbaum
    • , Dionysios A. Antonopoulos
    • , Jack A. Gilbert
    • , Luis B. Barreiro
    • , Olga Zaborina
    • , Bana Jabri
    •  & John C. Alverdy
  • Research |

    Disulfiram is an FDA-approved drug for treating alcoholism. Wu and colleagues show that disulfiram can be repurposed to efficiently inhibit pyroptosis by specifically blocking gasdermin-mediated pore formation.

    • Jun Jacob Hu
    • , Xing Liu
    • , Shiyu Xia
    • , Zhibin Zhang
    • , Ying Zhang
    • , Jingxia Zhao
    • , Jianbin Ruan
    • , Xuemei Luo
    • , Xiwen Lou
    • , Yang Bai
    • , Junhong Wang
    • , L. Robert Hollingsworth
    • , Venkat Giri Magupalli
    • , Li Zhao
    • , Hongbo R. Luo
    • , Justin Kim
    • , Judy Lieberman
    •  & Hao Wu
  • Research |

    Single-cell transcriptomic analysis identifies a distinct gene signature associated with peripheral monocyte populations that distinguishes people with sepsis from those with sterile inflammation and uninfected controls.

    • Miguel Reyes
    • , Michael R. Filbin
    • , Roby P. Bhattacharyya
    • , Kianna Billman
    • , Thomas Eisenhaure
    • , Deborah T. Hung
    • , Bruce D. Levy
    • , Rebecca M. Baron
    • , Paul C. Blainey
    • , Marcia B. Goldberg
    •  & Nir Hacohen
    Nature Medicine 26, 333-340

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