Sarcoma articles from across Nature Portfolio

Solitary fibrous tumours are mesenchymal tumours with an unpredictable progression and current medical treatments for relapsed SFTs remain ineffective. Here, the authors identified potential therapeutic targets and risk factors for SFTs and created an integrated risk model using 101 patients, and validated in 3 independent cohorts to successfully predict tumour progression.

Histologically, PAX3-FOXO1 (P3F) fusion-positive rhabdomyosarcoma (FP-RMS) resembles muscles cells, however, its cell-of-origin is less clear. Here, the authors demonstrate that P3F expression induces endothelial cells reprogramming into functional myogenic stem cells, driving the formation of FP-RMS in mouse models.