RNA vaccines

RNA vaccines are composed of the nucleic acid RNA, which encode antigen genes of an infectious agent. When administered to host cells, the RNA is translated into protein antigens that elicit protective immunity against the infectious agent.

Latest Research and Reviews

  • Research |

    • Kizzmekia S. Corbett
    • , Darin K. Edwards
    • , Sarah R. Leist
    • , Olubukola M. Abiona
    • , Seyhan Boyoglu-Barnum
    • , Rebecca A. Gillespie
    • , Sunny Himansu
    • , Alexandra Schäfer
    • , Cynthia T. Ziwawo
    • , Anthony T. DiPiazza
    • , Kenneth H. Dinnon
    • , Sayda M. Elbashir
    • , Christine A. Shaw
    • , Angela Woods
    • , Ethan J. Fritch
    • , David R. Martinez
    • , Kevin W. Bock
    • , Mahnaz Minai
    • , Bianca M. Nagata
    • , Geoffrey B. Hutchinson
    • , Kai Wu
    • , Carole Henry
    • , Kapil Bahi
    • , Dario Garcia-Dominguez
    • , LingZhi Ma
    • , Isabella Renzi
    • , Wing-Pui Kong
    • , Stephen D. Schmidt
    • , Lingshu Wang
    • , Yi Zhang
    • , Emily Phung
    • , Lauren A. Chang
    • , Rebecca J. Loomis
    • , Nedim Emil Altaras
    • , Elisabeth Narayanan
    • , Mihir Metkar
    • , Vlad Presnyak
    • , Cuiping Liu
    • , Mark K. Louder
    • , Wei Shi
    • , Kwanyee Leung
    • , Eun Sung Yang
    • , Ande West
    • , Kendra L. Gully
    • , Laura J. Stevens
    • , Nianshuang Wang
    • , Daniel Wrapp
    • , Nicole A. Doria-Rose
    • , Guillaume Stewart-Jones
    • , Hamilton Bennett
    • , Gabriela S. Alvarado
    • , Martha C. Nason
    • , Tracy J. Ruckwardt
    • , Jason S. McLellan
    • , Mark R. Denison
    • , James D. Chappell
    • , Ian N. Moore
    • , Kaitlyn M. Morabito
    • , John R. Mascola
    • , Ralph S. Baric
    • , Andrea Carfi
    •  & Barney S. Graham
    Nature, 1-8
  • Research |

    Results of an exploratory interim analysis from a phase I trial show that an RNA vaccine targeted towards four melanoma-associated antigens produces durable objective responses in patients with melanoma that are accompanied by strong CD4+ and CD8+ T-cell immunity.

    • Ugur Sahin
    • , Petra Oehm
    • , Evelyna Derhovanessian
    • , Robert A. Jabulowsky
    • , Mathias Vormehr
    • , Maike Gold
    • , Daniel Maurus
    • , Doreen Schwarck-Kokarakis
    • , Andreas N. Kuhn
    • , Tana Omokoko
    • , Lena M. Kranz
    • , Mustafa Diken
    • , Sebastian Kreiter
    • , Heinrich Haas
    • , Sebastian Attig
    • , Richard Rae
    • , Katarina Cuk
    • , Alexandra Kemmer-Brück
    • , Andrea Breitkreuz
    • , Claudia Tolliver
    • , Janina Caspar
    • , Juliane Quinkhardt
    • , Lisa Hebich
    • , Malte Stein
    • , Alexander Hohberger
    • , Isabel Vogler
    • , Inga Liebig
    • , Stephanie Renken
    • , Julian Sikorski
    • , Melanie Leierer
    • , Verena Müller
    • , Heidrun Mitzel-Rink
    • , Matthias Miederer
    • , Christoph Huber
    • , Stephan Grabbe
    • , Jochen Utikal
    • , Andreas Pinter
    • , Roland Kaufmann
    • , Jessica C. Hassel
    • , Carmen Loquai
    •  & Özlem Türeci
    Nature, 1-6
  • Research
    | Open Access

    Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in convalescent sera of patients.

    • Paul F. McKay
    • , Kai Hu
    • , Anna K. Blakney
    • , Karnyart Samnuan
    • , Jonathan C. Brown
    • , Rebecca Penn
    • , Jie Zhou
    • , Clément R. Bouton
    • , Paul Rogers
    • , Krunal Polra
    • , Paulo J. C. Lin
    • , Christopher Barbosa
    • , Ying K. Tam
    • , Wendy S. Barclay
    •  & Robin J. Shattock
  • Research
    | Open Access

    • Amy S. Espeseth
    • , Pedro J. Cejas
    • , Michael P. Citron
    • , Dai Wang
    • , Daniel J. DiStefano
    • , Cheryl Callahan
    • , Gregory O’ Donnell
    • , Jennifer D. Galli
    • , Ryan Swoyer
    • , Sinoeun Touch
    • , Zhiyun Wen
    • , Joseph Antonello
    • , Lan Zhang
    • , Jessica A. Flynn
    • , Kara S. Cox
    • , Daniel C. Freed
    • , Kalpit A. Vora
    • , Kapil Bahl
    • , Andrew H. Latham
    • , Jeffrey S. Smith
    • , Marian E. Gindy
    • , Giuseppe Ciaramella
    • , Daria Hazuda
    • , Christine A. Shaw
    •  & Andrew J. Bett
    npj Vaccines 5, 16

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