RNA transport articles within Nature

Cytoplasmic, amyloid-like oligomeric assemblies that contain TDP-43 are increased in damaged tissues with elevated regeneration, thereby enhancing the possibility of amyloid fibre formation and/or aggregation of TDP-43 in disease.

A sequence that is frequently found in Alu elements drives the localization of some long RNAs to the nucleus in human cells.

Heat shock drives the expression of transcripts that bypass mRNA quality control for direct export and translation, allowing cells to survive extreme situations at the cost of accuracy.

The cryo-electron microscopy structures of yeast nucleoplasmic pre-60S ribosomal particles give insight into the function of multiple assembly factors in ribosome biogenesis.

BRCA2, the breast cancer susceptibility gene factor, interacts with TREX-2, a protein complex involved in the biogenesis and export of messenger ribonucleoprotein, to process DNA–RNA hybrid structures called R-loops that can trigger genome instability; these may be a central cause of the stress occurring in early cancer cells that drives oncogenesis.

Newly synthesized messenger RNA is exported from the nucleus through nuclear pores. Here, a new imaging and tracking method has been developed to study the kinetics of mRNA export, with 20-ms time-precision and 26-nm spatial precision. A three-step model for export is presented, comprising docking, transport and release. Notably, mRNAs can move bi-directionally through the pore complex.