Article |
Featured
-
-
Article |
U1 snRNP regulates chromatin retention of noncoding RNAs
Long noncoding RNAs and certain unstable transcripts tend to localize to chromatin, in a process that is shown here to depend on an RNA motif that recognizes the small nuclear ribonuclear protein U1, and to rely on transcription.
- Yafei Yin
- , J. Yuyang Lu
- & Xiaohua Shen
-
Article |
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
Cytoplasmic, amyloid-like oligomeric assemblies that contain TDP-43 are increased in damaged tissues with elevated regeneration, thereby enhancing the possibility of amyloid fibre formation and/or aggregation of TDP-43 in disease.
- Thomas O. Vogler
- , Joshua R. Wheeler
- & Roy Parker
-
Letter |
Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells
A sequence that is frequently found in Alu elements drives the localization of some long RNAs to the nucleus in human cells.
- Yoav Lubelsky
- & Igor Ulitsky
-
Letter |
mRNA quality control is bypassed for immediate export of stress-responsive transcripts
Heat shock drives the expression of transcripts that bypass mRNA quality control for direct export and translation, allowing cells to survive extreme situations at the cost of accuracy.
- Gesa Zander
- , Alexandra Hackmann
- & Heike Krebber
-
Letter |
Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes
The cryo-electron microscopy structures of yeast nucleoplasmic pre-60S ribosomal particles give insight into the function of multiple assembly factors in ribosome biogenesis.
- Shan Wu
- , Beril Tutuncuoglu
- & Ning Gao
-
Letter |
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
BRCA2, the breast cancer susceptibility gene factor, interacts with TREX-2, a protein complex involved in the biogenesis and export of messenger ribonucleoprotein, to process DNA–RNA hybrid structures called R-loops that can trigger genome instability; these may be a central cause of the stress occurring in early cancer cells that drives oncogenesis.
- Vaibhav Bhatia
- , Sonia I. Barroso
- & Andrés Aguilera
-
Letter |
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export
- Ben Montpetit
- , Nathan D. Thomsen
- & Karsten Weis
-
Letter |
In vivo imaging of labelled endogenous β-actin mRNA during nucleocytoplasmic transport
Newly synthesized messenger RNA is exported from the nucleus through nuclear pores. Here, a new imaging and tracking method has been developed to study the kinetics of mRNA export, with 20-ms time-precision and 26-nm spatial precision. A three-step model for export is presented, comprising docking, transport and release. Notably, mRNAs can move bi-directionally through the pore complex.
- David Grünwald
- & Robert H. Singer
Nuclear export of circular RNA