RNA splicing

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns, splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and associated proteins, but there are also self-splicing introns.

Latest Research and Reviews

News and Comment

  • News and Views |

    Components of the spliceosome are frequently mutated in haematopoietic malignancies. Identification of mis-spliced genes promoting transformation will uncover novel targeted therapies. Now, a long isoform of IRAK4 is shown to be upregulated in a subset of acute myeloid leukaemia patients, conferring susceptibility for IRAK4 inhibition therapy.

    • Maria Guillamot
    •  & Iannis Aifantis
    Nature Cell Biology 21, 536-537
  • News and Views |

    The N6-methyladenosine modification next to the 5′ RNA cap has dynamic regulatory functions. Recent findings show that this modification regulates the splicing and translational activity of different classes of RNAs.

    • Richard A. Padgett
  • Research Highlights |

    A new study uses deep learning to predict genetic variants that generate cryptic splice sites and to investigate the role of these non-coding cryptic splice mutations in rare genetic disorders.

    • Dorothy Clyde