RNA nanotechnology articles within Nature Communications

Featured

  • Article
    | Open Access

    The development of RNA technologies demands accurate assessment of transcript size and heterogeneity. Here, authors report a nanopore-based approach to study full-length RNA transcripts at the single-molecule level, identify premature transcription termination and study rolling-circle transcription.

    • Gerardo Patiño-Guillén
    • , Jovan Pešović
    •  & Ulrich Felix Keyser

  • Article
    | Open Access

    Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold messenger and ribosomal RNA into 3D polyhedral structures.

    • Molly F. Parsons
    • , Matthew F. Allan
    •  & Mark Bathe

  • Article
    | Open Access

    Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.

    • Huanzhen Ni
    • , Marine Z. C. Hatit
    •  & James E. Dahlman

  • Article
    | Open Access

    The p53 tumor suppressor gene is frequently mutated in liver cancer. Here the authors show that restoration of p53 expression with a mRNA nanoparticle platform elicits anti-tumor immune responses and promotes response to immune checkpoint blockade in preclinical models of p53-null hepatocellular carcinoma.

    • Yuling Xiao
    • , Jiang Chen
    •  & Jinjun Shi

  • Article
    | Open Access

    DNA and RNA have been used for nanotechnology applications, though rarely in combination. Here the authors report the use of RNA motifs as structural joints with DNA building blocks for enhanced construction of small multi-component nanoshapes.

    • Alba Monferrer
    • , Douglas Zhang
    •  & Thomas Hermann

  • Article
    | Open Access

    Designing nucleic acid-based nanostructures with knots remains challenging. Here the authors present a general strategy to design and construct highly knotted 2D and 3D nanostructures from single-stranded DNA or RNA

    • Xiaodong Qi
    • , Fei Zhang
    •  & Hao Yan

  • Article
    | Open Access

    FRET has been used to study protein conformational changes but has never been applied to RNA aptamers. Here the authors develop a genetically encodable RNA aptamer-based FRET system on single-stranded RNA origami scaffolds, and demonstrate it can be used to study RNA conformational changes.

    • Mette D. E. Jepsen
    • , Steffen M. Sparvath
    •  & Ebbe S. Andersen

  • Article |

    Nucleic acids possess a number of properties that can be beneficial for the fabrication of nanomaterials. Here, the authors present an enzymatically synthesised RNA membrane, and show how its physical properties can be controlled by changes to base-pairing.

    • Daehoon Han
    • , Yongkuk Park
    •  & Jong Bum Lee

Browse broader subjects

Browse RNA nanotechnology across other nature.com journals