RNA editing | Nature

Article | 05 October 2022

Programmable RNA sensing for cell monitoring and manipulation

RNA sensing-mediated payload expression provides a specific, versatile, simple and generalizable means of detecting and manipulating animal cells with broad potential applications.

Yongjun Qian
, Jiayun Li
& Z. Josh Huang

Article | 03 August 2022

RNA editing underlies genetic risk of common inflammatory diseases

cis-RNA editing quantitative trait loci, which are associated with immunogenic double-stranded RNAs, underlie genome-wide association study variants in common autoimmune and inflammatory diseases.

Qin Li
, Michael J. Gloudemans
& Jin Billy Li

Article | 27 April 2022

Breakage of cytoplasmic chromosomes by pathological DNA base excision repair

DNA damage during chromothripsis is caused by deoxyinosine formation on accumulated RNA–DNA hybrids in micronuclei that are then recognized by N-methyl-purine DNA glycosylase and cleaved by apurinic/apyrimidinic endonuclease.

Shangming Tang
, Ema Stokasimov
& David Pellman

Letter | 12 October 2017

Dynamic landscape and regulation of RNA editing in mammals

Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

Meng How Tan
, Qin Li
& Jin Billy Li

Letter | 24 February 2013

CPEB1 coordinates alternative 3′-UTR formation with translational regulation

CPEB1 is known to regulate cytoplasmic polyadenylation, and is now shown to have a second function in the nucleus; it associates with the cleavage and polyadenylation machinery, thereby promoting usage of an upstream poly(A) signal in many messenger RNAs, and affecting alternative splicing.