RNA-binding proteins articles from across Nature Portfolio

This study developed a FUS chimera (FUSIBB) with a highly efficient anti-aggregation signal that is engaged by a nuclear import receptor, Importin beta. FUSIBB can mitigate aggregation and reduce expression of a neurodegeneration-linked protein, FUS.

Rift Valley fever virus is a WHO-prioritized zoonotic pathogen. The authors identified an RNA element on its genome that is devoid of nucleoprotein, has the potential for a hairpin structure, and is required for optimal transcription and replication.

The widespread OB fold recognizes diverse substrates from sugars to proteins and nucleic acids. Here the authors reveal how a class of OB fold proteins, exemplified by bacterial Trbp and yeast Arc1p, recognize tRNAs by their universal 3′-CCA ends.

ATE1 is an essential gene in mammals and is recognized as a master regulator of cells. Here, the authors describe structural insights into human ATE1, revealing mechanisms that regulate arginylation activity in cells.

The helix–turn–helix domain of an anti-CRISPR-associated (Aca) protein represses transcription of anti-CRISPR (Acr)-encoding genes and inhibits their translation to protein via distinct binding modes to DNA and RNA, respectively.

Biomolecular condensates are recognized for their ability to compartmentalize the cytoplasm without bounding membranes, but the degree to which they organize the cytoplasm has not been clear. A new study reveals that condensates at a scale of 100 nm are responsible for the organization of at least 18% of the cytoplasmic proteome.

A new study in Science reports the mechanism through which TDP-43 enables correct processing of STMN2 mRNA, and proposes strategies to restore neuronal Stathmin-2 synthesis in TDP-43 proteinopathies.