Ribosome

The ribosome is a large assembly of proteins and ribosomal RNAs (rRNAs) that functions to translate messenger RNAs (mRNAs) into proteins. The ribosome catalyzes the assembly of amino acids into peptide chains of defined sequence, as dictated by the interaction of amino-acid-carrying transport RNAs (tRNAs) with complementary sequences in the ribosome-bound mRNA.

Latest Research and Reviews

  • Research |

    • Yaara Finkel
    • , Orel Mizrahi
    • , Aharon Nachshon
    • , Shira Weingarten-Gabbay
    • , David Morgenstern
    • , Yfat Yahalom-Ronen
    • , Hadas Tamir
    • , Hagit Achdout
    • , Dana Stein
    • , Ofir Israeli
    • , Adi Beth-Din
    • , Sharon Melamed
    • , Shay Weiss
    • , Tomer Israely
    • , Nir Paran
    • , Michal Schwartz
    •  & Noam Stern-Ginossar
    Nature, 1-9
  • Research |

    The authors do a CRISPR-knockout selection to investigate host factors required for influenza replication. They identified IFIT2 as being repurposed by influenza to promote replication.

    • Vy Tran
    • , Mitchell P. Ledwith
    • , Thiprampai Thamamongood
    • , Christina A. Higgins
    • , Shashank Tripathi
    • , Max W. Chang
    • , Christopher Benner
    • , Adolfo García-Sastre
    • , Martin Schwemmle
    • , Adrianus C. M. Boon
    • , Michael S. Diamond
    •  & Andrew Mehle
  • Research
    | Open Access

    Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue.

    • Kai-Hsin Chan
    • , Valentyn Petrychenko
    • , Claudia Mueller
    • , Cristina Maracci
    • , Wolf Holtkamp
    • , Daniel N. Wilson
    • , Niels Fischer
    •  & Marina V. Rodnina
  • Research
    | Open Access

    Translation within mitochondria is carried out by specialized mitoribosomes and translational factors. Here the authors describe cryo-EM structures of the human mitochondrial translation elongation factor G1 in complex with human mitoribosomes, revealing distinct mechanism that include conformational changes at the polypeptide exit tunnel.

    • Ravi Kiran Koripella
    • , Manjuli R. Sharma
    • , Kalpana Bhargava
    • , Partha P. Datta
    • , Prem S. Kaushal
    • , Pooja Keshavan
    • , Linda L. Spremulli
    • , Nilesh K. Banavali
    •  & Rajendra K. Agrawal

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