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Article
| Open Access
Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy
Nerve damage can lead to skeletal muscle paralysis and atrophy. Here, the authors show that localized photostimulation of mouse calf muscle expressing the light-sensitive channel Channelrhodopsin-2 generates contraction in the absence of neural impulses and prove that this strategy can be used to prevent muscle atrophy.
- Philippe Magown
- , Basavaraj Shettar
- & Victor F. Rafuse
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Article
| Open Access
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism
The transcriptional regulator Tbx15 has a role in organ development. Here Lee et al.show that Tbx15 influences fibre-type determination in murine skeletal muscles, explaining local and systemic metabolic derangements in heterozygous Tbx15 knockout mice.
- Kevin Y. Lee
- , Manvendra K. Singh
- & C. Ronald Kahn
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Article
| Open Access
Turning terminally differentiated skeletal muscle cells into regenerative progenitors
Newts can regenerate amputated limbs via unknown mechanism involving dedifferentiation of cells in the stump into progenitors that contribute to the new appendages. Here the authors show that skeletal muscle dedifferentiation in regenerating newt limbs relies on a diverted programmed cell death response by myofibers.
- Heng Wang
- , Sara Lööf
- & András Simon
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Muscle stem cells contribute to myofibres in sedentary adult mice
Skeletal muscle satellite cells are muscle stem cells believed to contribute only to regenerating myofibres. Here Keefe et al. show that in adult sedentary mice satellite cells continue to fuse with uninjured myofibres, but they are not globally required for the maintenance of aging muscles.
- Alexandra C. Keefe
- , Jennifer A. Lawson
- & Gabrielle Kardon
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche