Restenosis articles from across Nature Portfolio

PDGF signaling plays a vital role in promoting neointimal hyperplasia. Here the authors show that PTPN14 dephosphorylates PDGFRβ Y692, which enhances PDGFRβ signaling activation, thereby aggravating neointimal hyperplasia.

An exosome-eluting stent improves vascular healing and reduces the rate of in-stent restenosis compared with either bare-metal stents or drug-eluting stents, according to a new study published in Nature Biomedical Engineering.

Patients with acute coronary syndromes have an increased risk of stent thrombosis. A considerable proportion of these patients are also at increased risk of bleeding, representing a challenge to optimal selection of stent type and duration of dual antiplatelet therapy. Recent evidence supports polymer-free drug-eluting stents as a safe and effective option for this challenging subset of patients.

Amin and colleagues have attempted to estimate the cost savings to the US health-care system if drug-eluting coronary stents were more selectively used in patients at low risk of restenosis. Their results and conclusions raise statistical, societal, and ethical issues that need to be considered before this approach should be widely embraced.