Respiratory system models

Respiratory system models are experimental systems that recreate aspects of human respiratory system development, function or disease. Animal models such as dog, rodent and pig can be used to study infectious and genetic respiratory illnesses.

Latest Research and Reviews

Research
30 November 2022 | Open Access

Combination of esomeprazole and pirfenidone enhances antifibrotic efficacy in vitro and in a mouse model of TGFβ-induced lung fibrosis
- Afshin Ebrahimpour
- , Manisha Ahir
- & Yohannes T. Ghebre
Scientific Reports 12, 20668
Research
19 January 2022 | Open Access

Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity

Yang et al. present an alveolar cell culture method that utilizes primary human alveolar epithelial cells, culturing cells in a small-molecule cocktail supplemented media. The authors show that the longevity of the primary cells culture can be expanded, and study human alveolar development, infection, injury repair, while demonstrating its use for SARS-CoV-2 infection.
- Jia-Wei Yang
- , Yu-Rou Lin
- & Guan-Yu Chen
Communications Biology 5, 70
Research
01 December 2021 | Open Access

Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease
- Ishita Choudhary
- , Thao Vo
- & Yogesh Saini
Scientific Reports 11, 23203
Research
16 September 2021 | Open Access

SSC-ILD mouse model induced by osmotic minipump delivered bleomycin: effect of Nintedanib
- Francesca Ravanetti
- , Erica Ferrini
- & Franco Fabio Stellari
Scientific Reports 11, 18513
Research
24 August 2021 | Open Access

Evaluation of a mechanical lung model to test small animal whole body plethysmography
- Swen Hülsmann
- , Amara Khan
- & Christian Dullin
Scientific Reports 11, 17099
Research
30 July 2021 | Open Access

Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis
- Maite Calucho
- , Silvia Gartner
- & Eduardo F. Tizzano
Scientific Reports 11, 15511

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News and Comment

Comments & Opinion
26 August 2020 | Open Access

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This commentary highlights an extraordinary international collaborative effort of independent researchers who have recently all come to the same conclusion—that chloroquine or hydroxchloroquine are unlikely to provide clinical benefit against COVID-19.
- S. G. P. Funnell
- , W. E. Dowling
- & C. M. Coleman
Nature Communications 11, 4253
Research Highlights | 19 April 2016

Club cells to the rescue
- Zoltan Fehervari
Nature Immunology 17, 480
Research Highlights | 09 August 2011

A new approach to respiratory recovery after spinal cord injury?
- Katie Kingwell
Nature Reviews Neurology 7, 473

All News & Comment

Respiratory system models

Latest Research and Reviews

Combination of esomeprazole and pirfenidone enhances antifibrotic efficacy in vitro and in a mouse model of TGFβ-induced lung fibrosis

Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity

Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease

SSC-ILD mouse model induced by osmotic minipump delivered bleomycin: effect of Nintedanib

Evaluation of a mechanical lung model to test small animal whole body plethysmography

Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis

News and Comment

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

Club cells to the rescue

A new approach to respiratory recovery after spinal cord injury?

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