Respiratory distress syndrome articles within Nature Communications

Featured

  • Article
    | Open Access

    There is a need for an accurate measure of pulmonary oxygenation function that can be used as an intermediate endpoint in pragmatic clinical trials, to increase statistical power and efficiency. Here, the authors show that the S/F94, a modification of the S/F ratio, is a simple, meaningful and effective intermediate outcome measure.

    • Maaike C. Swets
    • , Steven Kerr
    •  & J. Kenneth Baillie

  • Article
    | Open Access

    The molecular clock REV-ERBα regulates lung injury during fibrosis, but the role of REV-ERBα in fibrogenesis remains unknown. Here, the authors show that REV-ERBα interacts with the lysyl oxidase-collagen axis during fibrogenesis and demonstrate the therapeutic potential of Rev-erbα agonist against lung fibrosis.

    • Qixin Wang
    • , Isaac Kirubakaran Sundar
    •  & Irfan Rahman

  • Article
    | Open Access

    Retinoids can act as transcriptional regulators to regulate cell proliferation, differentiation, and other processes. Here, the authors show that uncompromised vitamin A (retinoid) metabolism and signaling in alveolar lipofibroblasts, endothelial and epithelial cells are required to lessen the severity of an acute inflammatory challenge in adult mouse lungs.

    • Igor O. Shmarakov
    • , Galina A. Gusarova
    •  & William S. Blaner

  • Article
    | Open Access

    No reliable serum biomarker for diffuse alveolar damage, a poor prognosis subtype of drug-induced interstitial lung disease, is currently available. Here, the authors show stratifin/14-3-3σ in serum is a promising biomarker for diagnosis of this type of disease.

    • Noriaki Arakawa
    • , Atsuhito Ushiki
    •  & Masayuki Hanaoka

  • Article
    | Open Access

    Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2+ buffering and surfactant secretion, and increased mortality, in response to LPS instillation, suggesting the MCU as a potential therapeutic target in ALI.

    • Mohammad Naimul Islam
    • , Galina A. Gusarova
    •  & Jahar Bhattacharya

  • Article
    | Open Access

    The reasons why malaria manifests with a variety of well-recognized clinical phenotypes remain poorly understood. Here, using distinct rodent models, the authors reveal that the microbiota colonizing the lung promotes respiratory distress syndrome and mortality during malaria infections.

    • Debanjan Mukherjee
    • , Ângelo Ferreira Chora
    •  & Maria M. Mota

  • Article
    | Open Access

    Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-CoV-2-induced lung injury in animal models.

    • Tomokazu Yamaguchi
    • , Midori Hoshizaki
    •  & Keiji Kuba

  • Article
    | Open Access

    How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.

    • Joseph S. Bednash
    • , Nathaniel Weathington
    •  & Rama K. Mallampalli

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