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A brainstem peptide system activated at birth protects postnatal breathing
A peptidergic brainstem circuit is identified that supports the initiation and establishment of breathing by providing a supplementary respiratory drive immediately after birth.
- Yingtang Shi
- , Daniel S. Stornetta
- & Douglas A. Bayliss
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Article |
Viral and host factors related to the clinical outcome of COVID-19
Genome sequences from 112 patients with confirmed SARS-CoV-2 infection showed two clades of SARS-CoV-2 virus with similar virulence and clinical outcome, and clinical data from 326 cases suggest that T cell depletion and cytokine bursts are associated with a worse prognosis.
- Xiaonan Zhang
- , Yun Tan
- & Hongzhou Lu
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Brief Communications Arising |
The role of Olfr78 in the breathing circuit of mice
- Hortensia Torres-Torrelo
- , Patricia Ortega-Sáenz
- & José López-Barneo
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Article |
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
The mechanoreceptor Piezo2 is required for both the Hering–Breuer inflation reflex in adult mice and the inflation of the lungs of newborn mice.
- Keiko Nonomura
- , Seung-Hyun Woo
- & Ardem Patapoutian
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Letter |
Oxygen regulation of breathing through an olfactory receptor activated by lactate
In addition to its role in olfaction, Olfr78 is involved in sensing hypoxia.
- Andy J. Chang
- , Fabian E. Ortega
- & Mark A. Krasnow
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Letter |
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity
Tissue-resident macrophages are shown to stop lipopolysaccharide-induced inflammation by spreading an anti-inflammatory calcium signal to alveolar epithelial cells through connexin-43-positive gap junction channels.
- Kristin Westphalen
- , Galina A. Gusarova
- & Jahar Bhattacharya
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Letter |
Unidirectional pulmonary airflow patterns in the savannah monitor lizard
Unlike the tidal (in and out) breathing of mammals, bird lungs have unidirectional airflow patterns; here the savannah monitor lizard is shown to have unidirectional airflow too, with profound implications for the evolution of unidirectional airflow in reptiles, predating the origin of birds.
- Emma R. Schachner
- , Robert L. Cieri
- & C. G. Farmer
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News & Views |
Drawing breath after spinal injury
New work on a rat model suggests that, after spinal-cord injury, restoration of sustained and robust respiratory function is possible using strategies that promote both neuronal plasticity and regeneration. See Article p.196
- Katherine Zukor
- & Zhigang He
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Research Highlights |
Bitter breath for lung airways
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Research Highlights |
Neurodegeneration: Cell respiration ruin
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News |
Breath of fresh air for brain 'glue' cells
Astrocytes may have an important role in regulating breathing.
- Miriam Frankel
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News |
Making lungs in the lab
Implanted tissue and microchip mimic both perform functions of lung.
- Alla Katsnelson
Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides