Reprogramming

Cell reprogramming is the process of reverting mature, specialised cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re-establishment of epigenetic marks during mammalian germ cell development.

Latest Research and Reviews

News and Comment

  • News and Views |

    Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now shown to engage YAP/TAZ to rewire cell mechanics and initiate tumorigenic reprogramming.

    • Sayan Chakraborty
    •  & Wanjin Hong
    Nature Materials 19, 707-709
  • News and Views |

    Cell identity is shaped by a complex interplay between transcription factors, enhancers and genome organisation. A study now reveals a dynamic role for the transcription factor KLF4 in directing gene regulatory interactions during pluripotent cell reprogramming, demonstrating that transcription factors can function as chromatin organisers.

    • Peter J. Rugg-Gunn
    Nature Cell Biology 21, 1173-1174
  • Research Highlights |

    A new study in Science reports the existence of a subpopulation of somatic cells from which ‘elite’ clones emerge that outperform other clones to drive reprogramming.

    • Linda Koch
  • News and Views |

    An in vivo cellular reprogramming strategy to generate epithelial cells from wound mesenchymal cells promotes healing and provides a new avenue for the treatment of nonhealing wounds.

    • Shruti Naik
    Nature Medicine 24, 1311-1312