Regulatory T cells

Regulatory T cells (TReg cells) are a special subset of T cells that prevent other immune cells from attacking the body’s own tissues and other harmless environmental materials, such as food and commensal organisms. Defects in regulatory T cells cause severe inflammatory disease.

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Latest Research and Reviews

  • Research |

    Type 1 diabetes (T1D) involves immune-mediated destruction of pancreatic β cells. Here, the authors show that inducing β-cell replication before immune cell infiltration of the pancreas alters β-cell antigen expression and prevents T1D disease progression in female NOD mice in a regulatory-T-cell-dependent manner.

    • Ercument Dirice
    • , Sevim Kahraman
    • , Dario F. De Jesus
    • , Abdelfattah El Ouaamari
    • , Giorgio Basile
    • , Rocky L. Baker
    • , Burcu Yigit
    • , Paul D. Piehowski
    • , Mi-Jeong Kim
    • , Alexander J. Dwyer
    • , Raymond W. S. Ng
    • , Cornelia Schuster
    • , Heidrun Vethe
    • , Tijana Martinov
    • , Yuki Ishikawa
    • , Adrian Kee Keong Teo
    • , Richard D. Smith
    • , Jiang Hu
    • , Kathryn Haskins
    • , Thomas Serwold
    • , Wei-Jun Qian
    • , Brian T. Fife
    • , Stephan Kissler
    •  & Rohit N. Kulkarni
    Nature Metabolism 1, 509-518
  • Research | | open

    Transcriptional regulator Rbpj is involved in T-helper subset differentiation. Here the authors show that expression of Rbpj in regulatory T cells is required to both regulate TH2 responses and regulate Treg TH2 differentiation potential.

    • Michael Delacher
    • , Christian Schmidl
    • , Yonatan Herzig
    • , Minka Breloer
    • , Wiebke Hartmann
    • , Fabian Brunk
    • , Danny Kägebein
    • , Ulrike Träger
    • , Ann-Cathrin Hofer
    • , Sebastian Bittner
    • , Dieter Weichenhan
    • , Charles D. Imbusch
    • , Agnes Hotz-Wagenblatt
    • , Thomas Hielscher
    • , Achim Breiling
    • , Giuseppina Federico
    • , Hermann-Josef Gröne
    • , Roland M. Schmid
    • , Michael Rehli
    • , Jakub Abramson
    •  & Markus Feuerer
  • Research | | open

    Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.

    • Martin Vaeth
    • , Yin-Hu Wang
    • , Miriam Eckstein
    • , Jun Yang
    • , Gregg J. Silverman
    • , Rodrigo S. Lacruz
    • , Kasthuri Kannan
    •  & Stefan Feske
  • Research | | open

    Interleukin-2 (IL-2) signaling is required for regulatory T (Treg) cell differentiation in the thymus, but its function in peripheral Tregs is still unclear. Here the authors show, using inducible deletion of IL-2 receptor subunit CD25, that IL-2 signaling is essential for maintaining peripheral Treg homeostasis, but dispensable for lineage stability.

    • Kevin H. Toomer
    • , Jen Bon Lui
    • , Norman H. Altman
    • , Yuguang Ban
    • , Xi Chen
    •  & Thomas R. Malek

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