Regeneration

Regeneration is the process by which lost or damaged tissues, organs or limbs are re-formed from the remaining tissue. During regeneration, adult stem cells and/or progenitor cells differentiate to replace the missing tissue, although in some instances differentiated cells can also participate in the regeneration by proliferation or transdifferentiation.

Latest Research and Reviews

Research
18 January 2023 | Open Access

Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration

Any planarian fragment regenerates the missing head and tail in the proper end. Early activation of the Wnt/β-catenin signaling pathway changes the chromatin accessibility of the cells of the posterior-facing wound to regenerate a tail.
- Eudald Pascual-Carreras
- , Marta Marín-Barba
- & Teresa Adell
Nature Communications 14, 298
Research
16 January 2023 | Open Access

MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts
- Qingyuan Ye
- , Xinyu Qiu
- & Yan Jin
International Journal of Oral Science 15, 7
Research
11 January 2023 | Open Access

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Cellular senescence and associated secretory phenotype (SASP) are thought to contribute to aging and tissue dysfunction, though it is unclear how SASP impacts regeneration. Here the authors show that SASP factors impair regeneration, and that Ptk7 is a key secreted protein mediating that dysregulation.
- Jina Yun
- , Simon Hansen
- & Heinrich Jasper
Nature Communications 14, 156
Research
06 January 2023 | Open Access

Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue
- Magdalena Plotczyk
- , Francisco Jiménez
- & Claire A. Higgins
npj Regenerative Medicine 8, 1
Reviews | 05 January 2023

Regulation of axonal regeneration after mammalian spinal cord injury

The inability of the mammalian central nervous system to functionally regenerate after injury is largely attributable to the limited capacity of injured neurons to regrow axons. In the spinal cord, recent work on the mechanisms restricting axon regrowth suggests new therapeutic avenues to promote functional recovery after damage.
- Binhai Zheng
- & Mark H. Tuszynski
Nature Reviews Molecular Cell Biology, 1-18
Research
05 January 2023 | Open Access

Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury

The dynamics of fibroadipogenic progenitors (FAPs) after muscle injury are crucial to ensure efficient regeneration. Here the authors show that a pool of FAPs originates from adipose tissue and are necessary for effective muscle regeneration.
- Quentin Sastourné-Arrey
- , Maxime Mathieu
- & Coralie Sengenès
Nature Communications 14, 80

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News and Comment

Research Highlights | 25 January 2023

Stem cell-derived organoid models: defying the Hayflick limit

In this Journal club, Meritxell Huch recalls a dogma postulated by Hayflick in 1961, that the capacity for propagating primary epithelial cells with normal ploidy is limited — a theory that persisted until the advent of organoid cultures.
- Meritxell Huch
Nature Reviews Genetics, 1
Research Highlights | 23 January 2023

Supreme regenerative skills help sea spiders to regrow guts and more

Other arthropods can regrow lost legs, but the sea spider can regenerate central organs all the way to the anus.

Nature
Research Highlights | 03 January 2023

Toes regrow with the help of these cells

Cells at the base of the nail are key to regeneration of missing digit tips.

Nature 613, 219
News & Views | 21 December 2022

Senescent cells damage the body throughout life

Cells in a state of arrested growth, called senescence, have been characterized in skeletal muscle in mice. Senescent cells promote inflammation and block regeneration, and thus might induce harmful changes in aged muscle.
- David J. Glass
Nature 613, 30-31
News & Views | 21 December 2022

Chasing youth on the outside: unique features of the human fetal epicardium

The epicardium has an active role in the formation of fetal and neonatal mammalian hearts, which retain the ability to regenerate. A single-cell comparison of human fetal and adult epicardial cells defines the transcriptomic programs that are specific to the fetal epicardium that could be harnessed to repair the injured adult heart.
- Anke M. Smits
- & Marie Jose Goumans
Nature Cardiovascular Research 1, 1130-1131
Research Highlights | 13 December 2022

Reindeer antlers model skin regeneration

Single-cell analysis of the regenerative velvet skin covering reindeer antlers during periods of growth shows that interactions between fibroblasts and immune cells determine wound healing outcomes.
- Kirsty Minton
Nature Reviews Immunology 23, 71

All News & Comment

Regeneration

Latest Research and Reviews

Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration

MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue

Regulation of axonal regeneration after mammalian spinal cord injury

Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury

News and Comment

Stem cell-derived organoid models: defying the Hayflick limit

Supreme regenerative skills help sea spiders to regrow guts and more

Toes regrow with the help of these cells

Senescent cells damage the body throughout life

Chasing youth on the outside: unique features of the human fetal epicardium

Reindeer antlers model skin regeneration

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