Nature

Rectal cancer

Rectal cancer is a cancer deriving from abnormal cell growth in the lining or epithelium of the rectum. Rectal and colorectal tumours are genetically considered to be the same cancer. Rectal cancer is a serious, but highly curable form of cancer if found early.

Latest Research and Reviews

Research
20 January 2023 | Open Access

PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation
- Lin Ren
- , Li Meng
- & Yan Ye
Cell Death & Disease 14, 44
Research
08 December 2022 | Open Access

Acute toxicities of patients with locally advanced rectal cancer treated with intensified chemoradiotherapy within the CAO/ARO/AIO-12 trial: comparing conventional versus VMAT planning at a single center
- Marcus Zimmermann
- , Anne Richter
- & Bülent Polat
Scientific Reports 12, 21263
Research
07 December 2022 | Open Access

The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer
- P. G. Alexander
- , H. C. van Wyk
- & J. H. Park
British Journal of Cancer, 1-12
Research
29 November 2022 | Open Access

m⁶A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation
- Wei Zeng
- , Jin-Feng Zhu
- & Wang-Jun Liao
Cell Death & Disease 13, 1008
Research | 15 August 2022

Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer

DNA and RNA sequencing in large cohorts of patients with rectal cancer treated with neoadjuvant therapies identifies biomarkers of response that could inform patient selection for non-operative treatment strategies.
- Walid K. Chatila
- , Jin K. Kim
- & Julio Garcia-Aguilar
Nature Medicine 28, 1646-1655
Research
03 August 2022 | Open Access

Cancer-associated fibroblasts-derived extracellular vesicles carrying lncRNA SNHG3 facilitate colorectal cancer cell proliferation via the miR-34b-5p/HuR/HOXC6 axis
- Jiangning Zhao
- , Huanrong Lin
- & Shen Li
Cell Death Discovery 8, 346

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News and Comment

Research Highlights | 06 October 2022

Laparoscopic TME is non-inferior
- Peter Sidaway
Nature Reviews Clinical Oncology 19, 748
Research Highlights | 27 September 2022

Robotic surgery for middle and low rectal cancer
- Eleni Kotsiliti
Nature Reviews Gastroenterology & Hepatology 19, 688
Research Highlights | 12 January 2021

Organ preservation versus radical surgery for early-stage rectal cancer
- Jordan Hindson
Nature Reviews Gastroenterology & Hepatology 18, 82
Research Highlights | 21 December 2020

Sequential CRT prior to surgery for rectal cancer
- David Killock
Nature Reviews Clinical Oncology 18, 64
Research Highlights | 23 January 2019

Rectal cancer — not a waiting game?
- David Killock
Nature Reviews Clinical Oncology 16, 209
Correspondence
02 January 2018 | Open Access

Comment on ‘Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system’
- Sandra Tapial
- , Daniel Rueda
- & José Perea
British Journal of Cancer 118, e3

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