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| Open AccessCryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ
Human T-cell lymphotropic virus type 1 (HTLV-1) is a pathogenic deltaretrovirus. Here the authors resolve the cryo-EM structure of the deltaretroviral intasome in complex with the human host PP2A regulatory subunit.
- Michał S. Barski
- , Jordan J. Minnell
- & Goedele N. Maertens
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| Open AccessUnmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
The integron integrases have evolved to perform recombination of single and double stranded DNA. Here the authors show that the ancestral pathway is still functional at double stranded sites, revealing the evolution towards the modern resolution pathway.
- Jose Antonio Escudero
- , Celine Loot
- & Didier Mazel
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| Open AccessSupporting conditional mouse mutagenesis with a comprehensive cre characterization resource
The cre-loxP system is widely used for the generation of conditional gene knockouts. Here Heffner et al.systematically characterize cre recombinase activity in tissues of embryonic and adult cre-driver mouse strains and provide an online resource for scientists.
- Caleb S. Heffner
- , C. Herbert Pratt
- & Stephen A. Murray