Recombinant vaccine articles from across Nature Portfolio

A recombinant vaccine is a vaccine produced through recombinant DNA technology. This involves inserting the DNA encoding an antigen (such as a bacterial surface protein) that stimulates an immune response into bacterial or mammalian cells, expressing the antigen in these cells and then purifying it from them.

Latest Research and Reviews

Research
15 March 2023 | Open Access

PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application
- Zhihao Zhang
- , Jinhu Zhou
- & Binlei Liu
npj Vaccines 8, 38
Research
16 December 2022 | Open Access

Safety and immunogenicity of SARS-CoV-2 vaccine MVC-COV1901 in Taiwanese adolescents: a randomized phase 2 trial
- Luke Tzu-Chi Liu
- , Cheng-Hsun Chiu
- & Li-Min Huang
npj Vaccines 7, 165
Research
09 November 2022 | Open Access

Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities
- Nathalie Charland
- , Philipe Gobeil
- & Brian J. Ward
npj Vaccines 7, 142
Research | 04 July 2022

Generation of a live attenuated influenza A vaccine by proteolysis targeting

Influenza virus is attenuated for vaccine production using PROTAC degradation technology.
- Longlong Si
- , Quan Shen
- & Roberto Plebani
Nature Biotechnology 40, 1370-1377
Research
22 April 2022 | Open Access

An adjuvanted zoster vaccine elicits potent cellular immune responses in mice without QS21
- Hyo Jung Nam
- , Sung Jun Hong
- & Eui-Cheol Shin
npj Vaccines 7, 45
Research
15 March 2022 | Open Access

Advances in purification of SARS-CoV-2 spike ectodomain protein using high-throughput screening and non-affinity methods
- Nicole Cibelli
- , Gabriel Arias
- & Daniel B. Gowetski
Scientific Reports 12, 4458

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News and Comment

Comments & Opinion
02 August 2022 | Open Access

Affordable SARS-CoV-2 protein vaccines for the pandemic endgame
- James A. Triccas
- , Joeri Kint
- & Florian M. Wurm
npj Vaccines 7, 89
News | 05 March 2018

Resurrection of a poxvirus causes alarm

A controversial study in which researchers generated an infectious horsepox virus using synthetic DNA and reverse genetics was recently reported.
- Ashley York
Nature Reviews Microbiology 16, 184
Correspondence | 09 July 2013

The case for semi-mandatory HPV vaccination in China
- Wen Jie Zhang
- , Feng Li
- & Yu Guang Cao
Nature Biotechnology 31, 590-591
News & Views | 10 April 2012

Selecting antigens for cancer vaccines

A cancer vaccine is streamlined by identifying a small set of potent immunogens in a tumor cDNA library.
- Francesca Avogadri
- & Jedd D Wolchok
Nature Biotechnology 30, 328-329
News & Views | 06 January 2011

Hepatitis E vaccination—is HEV 239 the breakthrough?

No approved vaccine is currently available against hepatitis E virus (HEV), which can cause acute hepatitis E. A large-scale phase III study involving more than 100,000 Chinese adults has reported that the recombinant HEV vaccine, HEV 239, prevented acute hepatitis E with a vaccine efficacy of 94–100%.
- Heiner Wedemeyer
- & Sven Pischke
Nature Reviews Gastroenterology & Hepatology 8, 8-10
Research Highlights | 01 March 2010

New vaccine platform?
- Alexandra Flemming
Nature Reviews Drug Discovery 9, 191

All News & Comment

Recombinant vaccine articles from across Nature Portfolio

Latest Research and Reviews

PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application

Safety and immunogenicity of SARS-CoV-2 vaccine MVC-COV1901 in Taiwanese adolescents: a randomized phase 2 trial

Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities

Generation of a live attenuated influenza A vaccine by proteolysis targeting

An adjuvanted zoster vaccine elicits potent cellular immune responses in mice without QS21

Advances in purification of SARS-CoV-2 spike ectodomain protein using high-throughput screening and non-affinity methods

News and Comment

Affordable SARS-CoV-2 protein vaccines for the pandemic endgame

Resurrection of a poxvirus causes alarm

The case for semi-mandatory HPV vaccination in China

Selecting antigens for cancer vaccines

Hepatitis E vaccination—is HEV 239 the breakthrough?

New vaccine platform?

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