Recombinant vaccine articles within Nature Communications

Featured

• Article
  13 August 2019 | Open Access

  Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

  Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from envenomation by a broad spectrum of elapid snakes.

  • Guillermo de la Rosa
  • , Felipe Olvera
  •  & Gerardo Corzo

• Article
  21 February 2019 | Open Access

  A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

  Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalent pneumococcal bioconjugate vaccine with polysaccharides containing glucose at their reducing end.

  • Christian M. Harding
  • , Mohamed A. Nasr
  •  & Mario F. Feldman