Reaction mechanisms articles from across Nature Portfolio

A reaction mechanism is a sequence of elementary reactions that can explain how an overall chemical reaction proceeds.


Latest Research and Reviews

News and Comment

  • Comments & Opinion |

    Automation and real-time reaction monitoring have enabled data-rich experimentation, which is critically important in navigating the complexities of chemical synthesis. Linking real-time analysis with machine learning and artificial intelligence tools provides the opportunity to accelerate the identification of optimal reaction conditions and facilitate error-free autonomous synthesis. This Comment provides a viewpoint underscoring the growing significance of data-rich experiments and interdisciplinary approaches in driving future progress in synthetic chemistry.

    • Junliang Liu
    •  & Jason E. Hein
  • News & Views |

    Dipolar cycloadditions are excellent processes for generating heterocyclic systems from simple starting materials, but arenes as dipolarophiles have not been extensively explored. Now, the intramolecular dipolar cycloaddition of aromatic rings has been achieved using in situ generated diazoalkenes to produce bicyclic or tricyclic heterocycles.

    • Abraham Ustoyev
    •  & Mitchell P. Croatt
    Nature Chemistry 15, 745-746
  • News & Views |

    The elementary steps of transition-metal catalysis can be thwarted by high energy barriers. Now, by designing light-harvesting ligands on rhodium centres, these barriers are lowered or circumvented by accessing the excited state of the metal, enabling otherwise challenging reactivity at room temperature.

    • Edward A. Anderson