Quality control articles from across Nature Portfolio

A new RNA reference set improves detection of differential expression in clinical settings.

Multi-omics data are readily integrated using quartet reference materials.

Using two different mass spectrometric platforms, authors demonstrate how metabolomic data fusion and multivariate analysis can be used to accurately identify the geographic origin and production method of salmon.

Dimension reduction (DR) is a key step of Cytometry by Time-of-Flight (CyTOF) data analysis. Here, the authors benchmark 21 DR methods on 110 real and 425 synthetic CyTOF samples, finding a high level of complementarity between the methods, and providing a comprehensive set of user guidelines.

The signal-to-noise ratio in bioimages is often low, which is problematic for segmentation. Here the authors report a deep learning method, deepflash2, to facilitate the segmentation of ambiguous bioimages through multi-expert annotations and integrated quality assurance.