Proteome

The proteome is the entire set of proteins produced by an organism or system and encoded by the full genome. A proteome may refer to the complement of proteins of a specific cell type (cellular proteome) or a subcellular system, as in a viral proteome or a nuclear proteome.

Latest Research and Reviews

  • Research |

    An advanced proteomics workflow is used to identify 340,000 proteins from 100 taxonomically diverse species, providing a comparative view of proteomes across the evolutionary range.

    • Johannes B. Müller
    • , Philipp E. Geyer
    • , Ana R. Colaço
    • , Peter V. Treit
    • , Maximilian T. Strauss
    • , Mario Oroshi
    • , Sophia Doll
    • , Sebastian Virreira Winter
    • , Jakob M. Bader
    • , Niklas Köhler
    • , Fabian Theis
    • , Alberto Santos
    •  & Matthias Mann
    Nature 582, 592-596
  • Research
    | Open Access

    Reimann, Schwäble et al. perform quantitative proteomics to study PI3K/Akt signaling in contracting myotubes. They identify a dual-site phosphorylation motif in the actin cross-linker and signaling adaptor filamin C, which regulates its degradation and mobility, suggesting the importance of dual phosphorylation for filamin C function in striated muscle cells.

    • Lena Reimann
    • , Anja N. Schwäble
    • , Anna L. Fricke
    • , Wignand W. D. Mühlhäuser
    • , Yvonne Leber
    • , Keerthika Lohanadan
    • , Martin G. Puchinger
    • , Sascha Schäuble
    • , Erik Faessler
    • , Heike Wiese
    • , Christa Reichenbach
    • , Bettina Knapp
    • , Christian D. Peikert
    • , Friedel Drepper
    • , Udo Hahn
    • , Clemens Kreutz
    • , Peter F. M. van der Ven
    • , Gerald Radziwill
    • , Kristina Djinović-Carugo
    • , Dieter O. Fürst
    •  & Bettina Warscheid
  • Research
    | Open Access

    Data-independent acquisition-mass spectrometry (MS) typically requires many preparatory MS runs to produce experiment-specific spectral libraries. Here, the authors show that empirical correction of in silico predicted spectral libraries enables efficient generation of high-quality experiment-specific libraries.

    • Brian C. Searle
    • , Kristian E. Swearingen
    • , Christopher A. Barnes
    • , Tobias Schmidt
    • , Siegfried Gessulat
    • , Bernhard Küster
    •  & Mathias Wilhelm
  • Research |

    Heat waves can pose a threat to biodiversity as heat stress kills sperm cells across the animal kingdom. Here, honey bee queens are found to be vulnerable to temperature changes and the specific stress-response proteins activated in the spermatheca are discussed as potential indicators of heat stress.

    • Alison McAfee
    • , Abigail Chapman
    • , Heather Higo
    • , Robyn Underwood
    • , Joseph Milone
    • , Leonard J. Foster
    • , M. Marta Guarna
    • , David R. Tarpy
    •  & Jeffery S. Pettis

News and Comment