Proteome

The proteome is the entire set of proteins produced by an organism or system and encoded by the full genome. A proteome may refer to the complement of proteins of a specific cell type (cellular proteome) or a subcellular system, as in a viral proteome or a nuclear proteome.

Latest Research and Reviews

Research | 04 February 2019 | open

Regional protein expression in human Alzheimer’s brain correlates with disease severity

Jingshu Xu et al. did a comprehensive post-mortem proteomics analysis across six brain regions obtained from Alzheimer’s disease patients and controls. With this spatial proteomics approach, they identified new disease-related pathways and a gradient of protein expression changes that correlates with the pathology of the affected regions.
- Jingshu Xu
- , Stefano Patassini
- , Nitin Rustogi
- , Isabel Riba-Garcia
- , Benjamin D. Hale
- , Alexander M Phillips
- , Henry Waldvogel
- , Robert Haines
- , Phil Bradbury
- , Adam Stevens
- , Richard L. M. Faull
- , Andrew W. Dowsey
- , Garth J. S. Cooper
- & Richard D. Unwin
Communications Biology 2, 43
Research | 17 January 2019 | open

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor in liver cancer
- Woo-Jeong Jeong
- , Jong-Chan Park
- , Woo-Shin Kim
- , Eun Ji Ro
- , Soung Hoo Jeon
- , Sang-Kyu Lee
- , Young Nyun Park
- , Do Sik Min
- & Kang-Yell Choi
Nature Communications 10, 295
Research | 02 November 2018

Laser capture microdissection–targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex
- Matthew L. MacDonald
- , Daley Favo
- , Megan Garver
- , Zhe Sun
- , Dominique Arion
- , Ying Ding
- , Nathan Yates
- , Robert A. Sweet
- & David A. Lewis
Neuropsychopharmacology 44, 743-748
Research | 10 October 2018 | open

More complete polarization of renal tubular epithelial cells by artificial urine
- Arada Vinaiphat
- , Komgrid Charngkaew
- & Visith Thongboonkerd
Cell Death Discovery 4, 47
Research | 02 October 2018 | open

Spider silk proteome provides insight into the structural characterization of Nephila clavipes flagelliform spidroin
- José Roberto Aparecido dos Santos-Pinto
- , Helen Andrade Arcuri
- , Franciele Grego Esteves
- , Mario Sergio Palma
- & Gert Lubec
Scientific Reports 8, 14674
Research | 15 August 2018 | open

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

Genetic variation can influence levels of disease-related plasma proteins and, thus, contribute to the pathogenesis of complex diseases. Here, the authors perform genome-wide QTL analysis for 71 plasma proteins to identify causal proteins for coronary heart disease and provide a molecular QTL browser.
- Chen Yao
- , George Chen
- , Ci Song
- , Joshua Keefe
- , Michael Mendelson
- , Tianxiao Huan
- , Benjamin B. Sun
- , Annika Laser
- , Joseph C. Maranville
- , Hongsheng Wu
- , Jennifer E. Ho
- , Paul Courchesne
- , Asya Lyass
- , Martin G. Larson
- , Christian Gieger
- , Johannes Graumann
- , Andrew D. Johnson
- , John Danesh
- , Heiko Runz
- , Shih-Jen Hwang
- , Chunyu Liu
- , Adam S. Butterworth
- , Karsten Suhre
- & Daniel Levy
Nature Communications 9, 3268

All Research & Reviews

News and Comment

Research Highlights | 03 January 2018

Proteomics: Nascent proteome labeling in vivo

Nature Methods 15, 15
Research Highlights | 14 June 2017

Translation: RAPping with ribosomes

Various proteins interact with ribosomes — this ribosome–protein interactome functionally diversifies ribosomes, thereby providing an additional means of translation regulation.
- Paulina Strzyz
Nature Reviews Molecular Cell Biology 18, 406
Research Highlights | 30 March 2016

Systems biology: Protein isoforms: more than meets the eye

Alternative splicing imparts distinct functions through isoform-specific protein–protein interactions.
- Stéphane Larochelle
Nature Methods 13, 291
Research Highlights | 10 February 2015

Gene expression: Spatial characterization of proteomes
- Darren J. Burgess
Nature Reviews Genetics 16, 129
News and Views | 07 June 2011

Human peptidome display

A peptide library representing the entire human proteome is applied to the discovery of autoantigens.
- William H Robinson
- & Lawrence Steinman
Nature Biotechnology 29, 500-502
News and Views | 20 March 2011

The myosin-II-responsive focal adhesion proteome: a tour de force?

The formation and maturation of focal adhesions involves significant changes in protein composition and requires acto-myosin contractility. A mass spectrometry approach reveals changes to the focal adhesion proteome on myosin inhibition, providing a valuable resource for the cell adhesion field.
- Lisa Gallegos
- , Mei Rosa Ng
- & Joan S. Brugge
Nature Cell Biology 13, 344-346

All News & Comment

Proteome

Latest Research and Reviews

Regional protein expression in human Alzheimer’s brain correlates with disease severity

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Laser capture microdissection–targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex

More complete polarization of renal tubular epithelial cells by artificial urine

Spider silk proteome provides insight into the structural characterization of Nephila clavipes flagelliform spidroin

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

News and Comment

Proteomics: Nascent proteome labeling in vivo

Translation: RAPping with ribosomes

Systems biology: Protein isoforms: more than meets the eye

Gene expression: Spatial characterization of proteomes

Human peptidome display

The myosin-II-responsive focal adhesion proteome: a tour de force?

Quick links

Proteome

Latest Research and Reviews

News and Comment

Search

Quick links