Protein transport articles from across Nature Portfolio

Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Here, the authors show that Sortilin in adipose tissues facilitates the translocation of ACSL1 from the mitochondria to the endolysosomal pathway for degradation, which controls adipose tissue fatty acid oxidation and substrate fuel selection during beige fat activation.

A high-content screening using a fluorescence readout has been used to identify pharmacological correctors of intracellularly-retained ABCB4 variants. The identified small molecules rescued canalicular targeting of ABCB4 variants.

Circadian gene expression is fundamental to the circadian clock. Here the author showed post-translational processing is the dominant contributor to circadian nuclear proteome and Environmental Circadian Disruption re-writes the entire gene expression process from transcription to post-translation.

Sun, Tao, Han et al. identify the Rabs involved in unconventional protein secretion mediated by TMED10 and in ER–Golgi intermediate compartment organization.

Visualizing the stages of herpesvirus nuclear egress in situ using cryoET and subvolume averaging shows how nascent virions pass through the nuclear membrane.

The mitochondrial translocase complex TIM23 targets several hundreds of proteins to their location in the mitochondrial matrix or inner membrane. Recent studies provide important structural and mechanistic insights into the actions of the protein-import machinery in mitochondria.

Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.