Protein–protein interaction networks articles from across Nature Portfolio

Daly, Danson and colleagues employ a multi-omic approach in neuroglioma cells to characterise endolysosomal dysfunction caused by perturbation of the evolutionarily conserved Retromer complex, highlighting Retromer’s neuroprotective function.

Protein-protein interactions underlie all aspects of a viral infection. Here the authors employ a pan-viral approach for systematic identification of motif-mediated interactions between viral and human proteins and show that the information can be used to find targets for antiviral drug development.

Heavy water metabolic labeling followed by liquid chromatography coupled mass spectrometry (LC-MS) is a powerful approach to characterize in vivo protein turnover rates, however, peptide co-elution causes overlap of their isotope profiles in LC-MS and affects the proteome coverage. Here, the authors develop an approach to increase the proteome coverage for in vivo protein turnover by using partial isotope profiles from two mass isotopomers.

Maps of protein-protein interactions (PPIs) help identify new components of pathways, complexes, and processes. In this work, state-of-the-art methods are used to identify binary Drosophila PPIs, generating broadly useful physical and data resources.